Looks to be incompatible with the PaX constification plugin:
> /tmp/nix-build-wireguard-unstable-2016-08-08.drv-0/WireGuard-experimental-0.0.20160808/src/device.c:329:29: error: constified variable 'link_ops' placed into writable section ".data..read_mostly"
static struct rtnl_link_ops link_ops __read_mostly = {
https://hydra.nixos.org/build/39671573/log/raw
See also https://github.com/NixOS/nixpkgs/issues/18209