diff --git a/pkgs/development/compilers/neko/default.nix b/pkgs/development/compilers/neko/default.nix
index 9edceead55e8..064e62dba9e2 100644
--- a/pkgs/development/compilers/neko/default.nix
+++ b/pkgs/development/compilers/neko/default.nix
@@ -1,50 +1,24 @@
-{ stdenv, fetchurl, fetchpatch, boehmgc, zlib, sqlite, pcre, cmake, pkgconfig
-, git, apacheHttpd, apr, aprutil, mariadb, mbedtls, openssl, pkgs, gtk2
+{ stdenv, fetchurl, boehmgc, zlib, sqlite, pcre, cmake, pkgconfig
+, git, apacheHttpd, apr, aprutil, mariadb, mbedtls, openssl, pkgs, gtk2, libpthreadstubs
 }:
 
 stdenv.mkDerivation rec {
   name = "neko-${version}";
-  version = "2.1.0";
+  version = "2.2.0";
 
   src = fetchurl {
     url = "http://nekovm.org/media/neko-${version}-src.tar.gz";
-    sha256 = "15ng9ad0jspnhj38csli1pvsv3nxm75f0nlps7i10194jvzdb4qc";
+    sha256 = "1qv47zaa0vzhjlq5wb71627n7dbsxpc1gqpg0hsngjxnbnh1q46g";
   };
 
-  # Patches backported with reference to https://github.com/HaxeFoundation/neko/issues/131
-  # They can probably be removed when bumping to next version
-  patches = [
-    (fetchpatch {
-      url = "https://github.com/HaxeFoundation/neko/commit/"
-          + "a8c71ad97faaccff6c6e9e09eba2d5efd022f8dc.patch";
-      sha256 = "0mnx15cdjs8mnl01mhc9z2gpzh4d1q0ygqnjackrqxz6x235ydyp";
-    })
-    (fetchpatch {
-      url = "https://github.com/HaxeFoundation/neko/commit/"
-          + "fe87462d9c7a6ee27e28f5be5e4fc0ac87b34574.patch";
-      sha256 = "1jbmq6j32vg3qv20dbh82cp54886lgrh7gkcqins8a2y4l4dl3sc";
-    })
-    # https://github.com/HaxeFoundation/neko/pull/165
-    (fetchpatch {
-      url = "https://github.com/HaxeFoundation/neko/commit/"
-          + "c6d9c6d796200990b3b6a53a4dc716c9192398e6.patch";
-      sha256 = "1pq0qhhb9gbhc3zbgylwp0amhwsz0q0ggpj6v2xgv0hfy7d63rcd";
-    })
-    # Glibc 2.26 no longer has xlocale.h, patch backported from upstream commit
-    # e286c8f3301fa443255a3101d14b7392467051b8.
-    ./xlocale-fix.patch
-  ];
-
+  nativeBuildInputs = [ cmake pkgconfig git ];
   buildInputs =
-    [ boehmgc zlib sqlite pcre cmake pkgconfig git apacheHttpd apr aprutil
-      mariadb.client mbedtls openssl ]
+    [ boehmgc zlib sqlite pcre apacheHttpd apr aprutil
+      mariadb.client mbedtls openssl libpthreadstubs ]
       ++ stdenv.lib.optional stdenv.isLinux gtk2
       ++ stdenv.lib.optionals stdenv.isDarwin [ pkgs.darwin.apple_sdk.frameworks.Security
                                                 pkgs.darwin.apple_sdk.frameworks.Carbon];
   cmakeFlags = [ "-DRUN_LDCONFIG=OFF" ];
-  prePatch = ''
-    sed -i -e '/allocated = strdup/s|"[^"]*"|"'"$out/lib/neko:$out/bin"'"|' vm/load.c
-  '';
 
   checkPhase = ''
     bin/neko bin/test.n
diff --git a/pkgs/development/compilers/neko/xlocale-fix.patch b/pkgs/development/compilers/neko/xlocale-fix.patch
deleted file mode 100644
index f4c53f3a43d6..000000000000
--- a/pkgs/development/compilers/neko/xlocale-fix.patch
+++ /dev/null
@@ -1,59 +0,0 @@
-commit 31d3ac3d691b2a1b07991e67302fd52b0f409cac
-Author: Andy Li <andy@onthewings.net>
-Date:   Thu Jul 13 13:23:33 2017 +0800
-
-    include xlocale.h only if it is available since it is removed in recent glibc
-    
-    see: https://bugzilla.redhat.com/show_bug.cgi?id=1464244
-    
-    (Backported from e286c8f3301fa443255a3101d14b7392467051b8)
-
-diff --git a/CMakeLists.txt b/CMakeLists.txt
-index 8de1702..d64cab9 100644
---- a/CMakeLists.txt
-+++ b/CMakeLists.txt
-@@ -1,5 +1,6 @@
- cmake_minimum_required(VERSION 2.8.7)
- 
-+include(CheckIncludeFile)
- project(neko C)
- 
- set(CMAKE_OSX_ARCHITECTURES x86_64)
-@@ -48,6 +49,8 @@ set(NEKO_VERSION_MAJOR 2)
- set(NEKO_VERSION_MINOR 1)
- set(NEKO_VERSION_PATCH 0)
- 
-+check_include_file(xlocale.h HAVE_XLOCALE_H)
-+
- configure_file (
- 	"${CMAKE_SOURCE_DIR}/vm/neko.h.in"
- 	"${CMAKE_BINARY_DIR}/neko.h"
-diff --git a/libs/std/sys.c b/libs/std/sys.c
-index 8003d41..ae0cfee 100644
---- a/libs/std/sys.c
-+++ b/libs/std/sys.c
-@@ -41,7 +41,11 @@
- #	include <sys/time.h>
- #	include <sys/times.h>
- #	include <sys/wait.h>
-+#ifdef HAVE_XLOCALE_H
- #	include <xlocale.h>
-+#else
-+#	include <locale.h>
-+#endif
- #endif
- 
- #ifdef NEKO_MAC
-diff --git a/vm/neko.h.in b/vm/neko.h.in
-index bb9ec1b..147ecce 100644
---- a/vm/neko.h.in
-+++ b/vm/neko.h.in
-@@ -88,6 +88,8 @@
- #	include <stdint.h>
- #endif
- 
-+#cmakedefine HAVE_XLOCALE_H
-+
- #define NEKO_VERSION_MAJOR	@NEKO_VERSION_MAJOR@
- #define NEKO_VERSION_MINOR	@NEKO_VERSION_MINOR@
- #define NEKO_VERSION_PATCH	@NEKO_VERSION_PATCH@