diff --git a/pkgs/development/libraries/nlohmann_json/default.nix b/pkgs/development/libraries/nlohmann_json/default.nix
index 59cc9438a9f1..0e9ff5d9105e 100644
--- a/pkgs/development/libraries/nlohmann_json/default.nix
+++ b/pkgs/development/libraries/nlohmann_json/default.nix
@@ -15,17 +15,16 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ cmake ];
 
-  doCheck = true;
+  doCheck = stdenv.buildPlatform == stdenv.hostPlatform;
   checkTarget = "test";
 
   enableParallelBuilding = true;
 
-  crossAttrs = {
-    cmakeFlags = "-DBuildTests=OFF";
-    doCheck = false;
-  } // stdenv.lib.optionalAttrs (hostPlatform.libc == "msvcrt") {
-    cmakeFlags = "-DBuildTests=OFF -DCMAKE_SYSTEM_NAME=Windows";
-  };
+  cmakeFlags = [
+    "-DBuildTests=${if doCheck then "ON" else "OFF"}"
+  ] ++ stdenv.lib.optionals (hostPlatform.libc == "msvcrt") [
+    "-DCMAKE_SYSTEM_NAME=Windows"
+  ];
 
   meta = with stdenv.lib; {
     description = "Header only C++ library for the JSON file format";
diff --git a/pkgs/games/prboom/default.nix b/pkgs/games/prboom/default.nix
index 4babc1caea5a..520f6503edfd 100644
--- a/pkgs/games/prboom/default.nix
+++ b/pkgs/games/prboom/default.nix
@@ -1,20 +1,31 @@
-{stdenv, fetchurl, SDL, SDL_mixer, SDL_net, libGLU_combined}:
+{ stdenv, fetchurl, SDL, SDL_mixer, SDL_net
+, libGLU_combined ? assert false; null
+, useOpenGL ? stdenv.hostPlatform == stdenv.buildPlatform
+}:
 
-stdenv.mkDerivation {
+stdenv.mkDerivation rec {
   name = "prboom-2.5.0";
   src = fetchurl {
     url = mirror://sourceforge/prboom/prboom-2.5.0.tar.gz;
     sha256 = "1bjb04q8dk232956k30qlpq6q0hxb904yh1nflr87jcc1x3iqv12";
   };
 
-  buildInputs = [ SDL SDL_mixer SDL_net libGLU_combined ];
-  crossAttrs = {
-    propagatedBuildInputs = [ SDL.crossDrv SDL_mixer.crossDrv SDL_net.crossDrv ];
-    configureFlags = "--disable-gl --disable-cpu-opt --without-x --disable-sdltest
-      ac_cv_type_uid_t=yes ac_cv_type_gid_t=yes";
+  buildInputs = [ SDL SDL_mixer SDL_net ]
+    ++ stdenv.lib.optional useOpenGL libGLU_combined;
 
-    postInstall = ''
-      mv $out/games/ $out/bin
-    '';
-  };
+  doCheck = stdenv.hostPlatform == stdenv.buildPlatform;
+
+  configureFlags = [
+    (stdenv.lib.enableFeature useOpenGL "gl")
+    (stdenv.lib.enableFeature doCheck "sdltest")
+  ] ++ stdenv.lib.optionals (stdenv.hostPlatform != stdenv.buildPlatform) [
+    "--disable-cpu-opt"
+    "--without-x"
+    "ac_cv_type_uid_t=yes"
+    "ac_cv_type_gid_t=yes"
+  ];
+
+  postInstall = stdenv.lib.optionalString (stdenv.hostPlatform != stdenv.buildPlatform) ''
+    mv $out/games/ $out/bin
+  '';
 }
diff --git a/pkgs/games/scummvm/default.nix b/pkgs/games/scummvm/default.nix
index f4590081898a..b9b95a5fb4dc 100644
--- a/pkgs/games/scummvm/default.nix
+++ b/pkgs/games/scummvm/default.nix
@@ -20,22 +20,16 @@ stdenv.mkDerivation rec {
 
   enableParallelBuilding = true;
 
+  configurePlatforms = [ "host" ];
   configureFlags = [
     "--enable-c++11"
     "--enable-release"
   ];
 
-  crossAttrs = {
-    preConfigure = ''
-      # Remove the --build flag set by the gcc cross wrapper setup
-      # hook
-      export configureFlags="--host=${hostPlatform.config}"
-    '';
-    postConfigure = ''
-      # They use 'install -s', that calls the native strip instead of the cross
-      sed -i 's/-c -s/-c/' ports.mk;
-    '';
-  };
+  # They use 'install -s', that calls the native strip instead of the cross
+  postConfigure = ''
+    sed -i "s/-c -s/-c -s --strip-program=''${STRIP@Q}" ports.mk
+  '';
 
   meta = with stdenv.lib; {
     description = "Program to run certain classic graphical point-and-click adventure games (such as Monkey Island)";
diff --git a/pkgs/os-specific/gnu/hurd/default.nix b/pkgs/os-specific/gnu/hurd/default.nix
index ae1c504fd19e..a0c4be0ff451 100644
--- a/pkgs/os-specific/gnu/hurd/default.nix
+++ b/pkgs/os-specific/gnu/hurd/default.nix
@@ -52,7 +52,8 @@ stdenv.mkDerivation ({
        done
     '';
 
-  crossAttrs.dontPatchShebangs = true;
+  # Not needed after https://github.com/NixOS/nixpkgs/pull/43833
+  dontPatchShebangs = stdenv.hostPlatform != stdenv.buildPlatform;
 
   meta = {
     description = "The GNU Hurd, GNU project's replacement for the Unix kernel";
diff --git a/pkgs/os-specific/gnu/mig/default.nix b/pkgs/os-specific/gnu/mig/default.nix
index 2855f5b4240f..d138011d595b 100644
--- a/pkgs/os-specific/gnu/mig/default.nix
+++ b/pkgs/os-specific/gnu/mig/default.nix
@@ -21,13 +21,11 @@ stdenv.mkDerivation {
 
   doCheck = true;
 
-  crossAttrs = {
-    postInstall =
-      # Fix the shebang to point to the cross-built shell.
-      '' sed -i "$out/bin/mig" \
-             -e 's|^#!/.*|#!${bash.crossDrv}/bin/sh|g'
-      '';
-  };
+  # Fix the shebang to point to the cross-built shell. Won't be needed
+  # after #43833.
+  postInstall = ''
+    sed -i "$out/bin/mig" -e 's|^#!/.*|#!${bash}/bin/sh|g'
+  '';
 
   meta = {
     description = "GNU MIG, the Mach interface generator";
diff --git a/pkgs/os-specific/windows/jom/default.nix b/pkgs/os-specific/windows/jom/default.nix
index 8befa51566de..1b64ad745991 100644
--- a/pkgs/os-specific/windows/jom/default.nix
+++ b/pkgs/os-specific/windows/jom/default.nix
@@ -17,13 +17,11 @@ stdenv.mkDerivation {
 
   QTDIR = qt48;
   
-  crossAttrs = {
-    # cmakeFlags = "-DWIN32=1 -DCMAKE_SYSTEM_NAME=Windows -DCMAKE_RC_COMPILER=${stdenv.cc.targetPrefix}windres";
-    QTDIR = qt48.crossDrv;
-    preBuild = ''
-      export NIX_CROSS_CFLAGS_COMPILE=-fpermissive
-    '';
-  };
+  # cmakeFlags = "-DWIN32=1 -DCMAKE_SYSTEM_NAME=Windows -DCMAKE_RC_COMPILER=${stdenv.cc.targetPrefix}windres";
+
+  preBuild = stdenv.lib.optionalString (stdenv.hostPlatform != stdenv.buildPlatform) ''
+    export NIX_CROSS_CFLAGS_COMPILE=-fpermissive
+  '';
 
   meta = {
     homepage = http://qt-project.org/wiki/jom;