diff --git a/pkgs/by-name/ab/abpoa/package.nix b/pkgs/by-name/ab/abpoa/package.nix
new file mode 100644
index 000000000000..361f80a3b5e5
--- /dev/null
+++ b/pkgs/by-name/ab/abpoa/package.nix
@@ -0,0 +1,102 @@
+{
+  lib,
+  stdenv,
+  fetchFromGitHub,
+  simde,
+  zlib,
+  enableSse4_1 ? stdenv.hostPlatform.sse4_1Support,
+  enableAvx ? stdenv.hostPlatform.avxSupport,
+  enablePython ? false,
+  python3Packages,
+  runCommand,
+  abpoa,
+}:
+
+stdenv.mkDerivation (finalAttrs: {
+  pname = "${lib.optionalString enablePython "py"}abpoa";
+  version = "1.5.1";
+
+  src = fetchFromGitHub {
+    owner = "yangao07";
+    repo = "abPOA";
+    rev = "refs/tags/v${finalAttrs.version}";
+    hash = "sha256-nPMzkWkjUI+vZExNEvJa24KrR0pWGk89Mvp7TCyka/w=";
+  };
+
+  patches = [ ./simd-arch.patch ];
+
+  postPatch = ''
+    cp -r ${simde.src}/* include/simde
+    substituteInPlace Makefile \
+      --replace-fail "-march=native" ""
+  '';
+
+  nativeBuildInputs = lib.optionals enablePython (
+    with python3Packages;
+    [
+      cython
+      pypaBuildHook
+      pypaInstallHook
+      pythonImportsCheckHook
+      setuptools
+    ]
+  );
+
+  buildFlags = lib.optionals stdenv.hostPlatform.isx86_64 [
+    (
+      if enableAvx then
+        "avx2=1"
+      else if enableSse4_1 then
+        "sse41=1"
+      else
+        "sse2=1"
+    )
+  ];
+
+  env = lib.optionalAttrs enablePython (
+    if enableAvx then
+      { "AVX2" = 1; }
+    else if enableSse4_1 then
+      { "SSE41" = 1; }
+    else
+      { "SSE2" = 1; }
+  );
+
+  buildInputs = [ zlib ];
+
+  installPhase = lib.optionalString (!enablePython) ''
+    runHook preInstall
+
+    install -Dm755 ./bin/abpoa -t $out/bin
+
+    runHook postInstall
+  '';
+
+  pythonImportsCheck = [ "pyabpoa" ];
+
+  doInstallCheck = enablePython;
+
+  installCheckPhase = ''
+    runHook preInstallCheck
+
+    python python/example.py
+
+    runHook postInstallCheck
+  '';
+
+  passthru.tests = {
+    simple = runCommand "${finalAttrs.pname}-test" { } ''
+      ${lib.getExe abpoa} ${abpoa.src}/test_data/seq.fa > $out
+    '';
+  };
+
+  meta = with lib; {
+    description = "SIMD-based C library for fast partial order alignment using adaptive band";
+    homepage = "https://github.com/yangao07/abPOA";
+    changelog = "https://github.com/yangao07/abPOA/releases/tag/${finalAttrs.src.rev}";
+    license = licenses.mit;
+    maintainers = with maintainers; [ natsukium ];
+    mainProgram = "abpoa";
+    platforms = platforms.unix;
+  };
+})
diff --git a/pkgs/by-name/ab/abpoa/simd-arch.patch b/pkgs/by-name/ab/abpoa/simd-arch.patch
new file mode 100644
index 000000000000..424a2a4711d5
--- /dev/null
+++ b/pkgs/by-name/ab/abpoa/simd-arch.patch
@@ -0,0 +1,27 @@
+diff --git a/setup.py b/setup.py
+index 52c0e7e..f88ec08 100644
+--- a/setup.py
++++ b/setup.py
+@@ -11,11 +11,12 @@ simde = ['-DUSE_SIMDE', '-DSIMDE_ENABLE_NATIVE_ALIASES']
+ 
+ if platform.system() == "Darwin":
+     # note: see https://github.com/pypa/wheel/issues/406
+-    simd_flag = ['-march=native', '-D__AVX2__', '-mmacosx-version-min=10.9']
+     if platform.machine() in ["aarch64", "arm64"]:
++        simd_flag = ['-march=armv8-a+simd', '-D__AVX2__', '-mmacosx-version-min=10.9']
+         os.environ['_PYTHON_HOST_PLATFORM'] = "macosx-10.9-arm64"
+         os.environ['ARCHFLAGS'] = "-arch arm64"
+     else:
++        simd_flag = ['-msse2', '-mmacosx-version-min=10.9']
+         os.environ['_PYTHON_HOST_PLATFORM'] = "macosx-10.9-x86_64"
+         os.environ['ARCHFLAGS'] = "-arch x86_64"
+ else:
+@@ -24,7 +25,7 @@ else:
+     elif platform.machine() in ["aarch32"]:
+         simd_flag = ['-march=armv8-a+simd', '-mfpu=auto -D__AVX2__']
+     else:
+-        simd_flag=['-march=native']
++        simd_flag=[]
+         if os.getenv('SSE4', False):
+             simd_flag=['-msse4.1']
+         elif os.getenv('SSE2', False):
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 4837be366cb2..faede773664f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10041,6 +10041,11 @@ self: super: with self; {
 
   py65 = callPackage ../development/python-modules/py65 { };
 
+  pyabpoa = toPythonModule (pkgs.abpoa.override {
+    enablePython = true;
+    python3Packages = self;
+  });
+
   pyaehw4a1 = callPackage ../development/python-modules/pyaehw4a1 { };
 
   pyatag = callPackage ../development/python-modules/pyatag { };