diff --git a/pkgs/development/python-modules/systemd/default.nix b/pkgs/development/python-modules/systemd/default.nix
index 86c330bd1d88..b27af96edbd7 100644
--- a/pkgs/development/python-modules/systemd/default.nix
+++ b/pkgs/development/python-modules/systemd/default.nix
@@ -1,4 +1,10 @@
-{ lib, buildPythonPackage, fetchFromGitHub, systemd, pkg-config }:
+{ lib
+, buildPythonPackage
+, fetchpatch
+, fetchFromGitHub
+, systemd
+, pkg-config
+}:
 
 buildPythonPackage rec {
   pname = "systemd";
@@ -11,14 +17,36 @@ buildPythonPackage rec {
     sha256 = "1fakw7qln44mfd6pj4kqsgyrhkc6cyr653id34kv0rdnb1bvysrz";
   };
 
-  buildInputs = [ systemd ];
-  nativeBuildInputs = [ pkg-config ];
+  patches = [
+    # Fix runtime issues on Python 3.10
+    # https://github.com/systemd/python-systemd/issues/107
+    (fetchpatch {
+      url = "https://github.com/systemd/python-systemd/commit/c71bbac357f0ac722e1bcb2edfa925b68cca23c9.patch";
+      sha256 = "22s72Wa/BCwNNvwbxEUh58jhHlbA00SNwNVchVDovcc=";
+    })
+  ];
 
+  nativeBuildInputs = [
+    pkg-config
+  ];
+
+  buildInputs = [
+    systemd
+  ];
+
+  # No module named 'systemd._journal
   doCheck = false;
 
+  pythonImportsCheck = [
+    "systemd.journal"
+    "systemd.id128"
+    "systemd.daemon"
+    "systemd.login"
+  ];
+
   meta = with lib; {
     description = "Python module for native access to the systemd facilities";
     homepage = "http://www.freedesktop.org/software/systemd/python-systemd/";
-    license = licenses.lgpl21;
+    license = licenses.lgpl21Plus;
   };
 }