diff --git a/doc/hooks/python.section.md b/doc/hooks/python.section.md
index ecaae491e994..b7862650f167 100644
--- a/doc/hooks/python.section.md
+++ b/doc/hooks/python.section.md
@@ -1,3 +1,3 @@
 # Python {#setup-hook-python}
 
-Adds the `lib/${python.libPrefix}/site-packages` subdirectory of each build input to the `PYTHONPATH` environment variable.
+Adds the `python.sitePackages` subdirectory (i.e. `lib/pythonX.Y/site-packages`) of each build input to the `PYTHONPATH` environment variable.
diff --git a/pkgs/applications/misc/gramps/default.nix b/pkgs/applications/misc/gramps/default.nix
index 9d11b7e46e00..7539b22087c3 100644
--- a/pkgs/applications/misc/gramps/default.nix
+++ b/pkgs/applications/misc/gramps/default.nix
@@ -80,21 +80,21 @@ buildPythonApplication rec {
   installPhase = ''
     runHook preInstall
 
-    mkdir -p "$out/lib/${python.libPrefix}/site-packages"
+    mkdir -p "$out/${python.sitePackages}"
 
-    export PYTHONPATH="$out/lib/${python.libPrefix}/site-packages:$PYTHONPATH"
+    export PYTHONPATH="$out/${python.sitePackages}:$PYTHONPATH"
 
     ${python}/bin/${python.executable} setup.py install \
-      --install-lib=$out/lib/${python.libPrefix}/site-packages \
+      --install-lib=$out/${python.sitePackages} \
       --prefix="$out"
 
-    eapth="$out/lib/${python.libPrefix}"/site-packages/easy-install.pth
+    eapth="$out/${python.sitePackages}/easy-install.pth"
     if [ -e "$eapth" ]; then
         # move colliding easy_install.pth to specifically named one
         mv "$eapth" $(dirname "$eapth")/${pname}-${version}.pth
     fi
 
-    rm -f "$out/lib/${python.libPrefix}"/site-packages/site.py*
+    rm -f "$out/${python.sitePackages}"/site.py*
 
     runHook postInstall
   '';
diff --git a/pkgs/applications/misc/loxodo/default.nix b/pkgs/applications/misc/loxodo/default.nix
index 78d01af1f08b..77dd39bc0601 100644
--- a/pkgs/applications/misc/loxodo/default.nix
+++ b/pkgs/applications/misc/loxodo/default.nix
@@ -22,7 +22,7 @@ python3.pkgs.buildPythonApplication {
     [Desktop Entry]
     Type=Application
     Exec=$out/bin/loxodo
-    Icon=$out/lib/${python3.libPrefix}/site-packages/resources/loxodo-icon.png
+    Icon=$out/${python3.sitePackages}/resources/loxodo-icon.png
     Name=Loxodo
     GenericName=Password Vault
     Categories=Application;Other;
diff --git a/pkgs/applications/networking/mkchromecast/default.nix b/pkgs/applications/networking/mkchromecast/default.nix
index fa734e7dea53..f6364f5ba572 100644
--- a/pkgs/applications/networking/mkchromecast/default.nix
+++ b/pkgs/applications/networking/mkchromecast/default.nix
@@ -70,11 +70,11 @@ python3Packages.buildPythonApplication {
   ];
 
   postInstall = ''
-    substituteInPlace $out/lib/${python3Packages.python.libPrefix}/site-packages/mkchromecast/video.py \
+    substituteInPlace $out/${python3Packages.python.sitePackages}/mkchromecast/video.py \
       --replace '/usr/share/mkchromecast/nodejs/' '${placeholder "out"}/share/mkchromecast/nodejs/'
   '' + lib.optionalString stdenv.isDarwin ''
     install -Dm 755 -t $out/bin bin/audiodevice
-    substituteInPlace $out/lib/${python3Packages.python.libPrefix}/site-packages/mkchromecast/audio_devices.py \
+    substituteInPlace $out/${python3Packages.python.sitePackages}/mkchromecast/audio_devices.py \
       --replace './bin/audiodevice' '${placeholder "out"}/bin/audiodevice'
   '';
 
diff --git a/pkgs/applications/networking/p2p/deluge/default.nix b/pkgs/applications/networking/p2p/deluge/default.nix
index 54c378a08625..35db62ef8e4e 100644
--- a/pkgs/applications/networking/p2p/deluge/default.nix
+++ b/pkgs/applications/networking/p2p/deluge/default.nix
@@ -77,7 +77,7 @@ let
         install -Dm444 -t $out/share/applications deluge/ui/data/share/applications/deluge.desktop
       '' else ''
         rm -r $out/bin/deluge-gtk
-        rm -r $out/lib/${python3Packages.python.libPrefix}/site-packages/deluge/ui/gtk3
+        rm -r $out/${python3Packages.python.sitePackages}/deluge/ui/gtk3
         rm -r $out/share/{icons,man/man1/deluge-gtk*,pixmaps}
       '');
 
diff --git a/pkgs/applications/office/paperwork/paperwork-gtk.nix b/pkgs/applications/office/paperwork/paperwork-gtk.nix
index e21379678a17..e783e8f4966f 100644
--- a/pkgs/applications/office/paperwork/paperwork-gtk.nix
+++ b/pkgs/applications/office/paperwork/paperwork-gtk.nix
@@ -64,7 +64,7 @@ python3Packages.buildPythonApplication rec {
     # fixes [WARNING] [openpaperwork_core.resources.setuptools] Failed to find
     # resource file paperwork_gtk.icon.out/paperwork_128.png, tried at path
     # /nix/store/3n5lz6y8k9yks76f0nar3smc8djan3xr-paperwork-2.0.2/lib/python3.8/site-packages/paperwork_gtk/icon/out/paperwork_128.png.
-    site=$out/lib/${python3Packages.python.libPrefix}/site-packages/paperwork_gtk
+    site=$out/${python3Packages.python.sitePackages}/paperwork_gtk
     for i in $site/data/paperwork_*.png; do
       ln -s $i $site/icon/out;
     done
diff --git a/pkgs/applications/science/biology/obitools/obitools3.nix b/pkgs/applications/science/biology/obitools/obitools3.nix
index b38af2f64b54..9bf579a80c3b 100644
--- a/pkgs/applications/science/biology/obitools/obitools3.nix
+++ b/pkgs/applications/science/biology/obitools/obitools3.nix
@@ -17,8 +17,8 @@ python3Packages.buildPythonApplication rec {
   '';
 
   preBuild = ''
-    substituteInPlace src/CMakeLists.txt --replace \$'{PYTHONLIB}' "$out/lib/${python3.libPrefix}/site-packages";
-    export NIX_CFLAGS_COMPILE="-L $out/lib/${python3.libPrefix}/site-packages $NIX_CFLAGS_COMPILE"
+    substituteInPlace src/CMakeLists.txt --replace \$'{PYTHONLIB}' "$out/${python3.sitePackages}";
+    export NIX_CFLAGS_COMPILE="-L $out/${python3.sitePackages} $NIX_CFLAGS_COMPILE"
   '';
 
   dontConfigure = true;
diff --git a/pkgs/applications/version-management/mercurial/default.nix b/pkgs/applications/version-management/mercurial/default.nix
index 07cc4e7b8f58..058d01233889 100644
--- a/pkgs/applications/version-management/mercurial/default.nix
+++ b/pkgs/applications/version-management/mercurial/default.nix
@@ -62,7 +62,7 @@ let
       cp contrib/hgk $out/bin
       cat >> $out/etc/mercurial/hgrc << EOF
       [extensions]
-      hgk=$out/lib/${python.libPrefix}/site-packages/hgext/hgk.py
+      hgk=$out/${python.sitePackages}/hgext/hgk.py
       EOF
       # setting HG so that hgk can be run itself as well (not only hg view)
       WRAP_TK=" --set TK_LIBRARY ${tk}/lib/${tk.libPrefix}
diff --git a/pkgs/by-name/on/onedrivegui/package.nix b/pkgs/by-name/on/onedrivegui/package.nix
index f2db95e7dbc2..f9d1fca67539 100644
--- a/pkgs/by-name/on/onedrivegui/package.nix
+++ b/pkgs/by-name/on/onedrivegui/package.nix
@@ -74,7 +74,7 @@ python3Packages.buildPythonApplication rec {
     makeWrapper ${python3Packages.python.interpreter} $out/bin/onedrivegui \
       --prefix PATH : ${lib.makeBinPath [ onedrive ]} \
       --prefix PYTHONPATH : ${python3Packages.makePythonPath (propagatedBuildInputs ++ [(placeholder "out")])} \
-      --add-flags $out/lib/${python3Packages.python.libPrefix}/site-packages/OneDriveGUI.py
+      --add-flags $out/${python3Packages.python.sitePackages}/OneDriveGUI.py
   '';
 
   meta = with lib; {
diff --git a/pkgs/development/libraries/science/networking/ns-3/default.nix b/pkgs/development/libraries/science/networking/ns-3/default.nix
index dd28553d60e9..fa6e5e48f846 100644
--- a/pkgs/development/libraries/science/networking/ns-3/default.nix
+++ b/pkgs/development/libraries/science/networking/ns-3/default.nix
@@ -120,7 +120,7 @@ stdenv.mkDerivation rec {
     "-DPython3_EXECUTABLE=${pythonEnv}/bin/python"
     "-DNS3_PYTHON_BINDINGS=ON"
     "-DNS3_DES_METRICS=ON"
-    "-DNS3_BINDINGS_INSTALL_DIR=lib/${pythonEnv.libPrefix}/site-packages"
+    "-DNS3_BINDINGS_INSTALL_DIR=${pythonEnv.sitePackages}"
     "-DNS3_LOG=ON"
     "-DNS3_ASSERT=ON"
     "-DNS3_GTK3=ON"
diff --git a/pkgs/development/libraries/vigra/default.nix b/pkgs/development/libraries/vigra/default.nix
index 320b43f0e51b..677406d275a8 100644
--- a/pkgs/development/libraries/vigra/default.nix
+++ b/pkgs/development/libraries/vigra/default.nix
@@ -44,7 +44,7 @@ stdenv.mkDerivation rec {
     python
   ];
 
-  preConfigure = "cmakeFlags+=\" -DVIGRANUMPY_INSTALL_DIR=$out/lib/${python.libPrefix}/site-packages\"";
+  preConfigure = "cmakeFlags+=\" -DVIGRANUMPY_INSTALL_DIR=$out/${python.sitePackages}\"";
 
   cmakeFlags = [ "-DWITH_OPENEXR=1" ]
     ++ lib.optionals (stdenv.hostPlatform.system == "x86_64-linux")
diff --git a/pkgs/development/python-modules/apache-beam/default.nix b/pkgs/development/python-modules/apache-beam/default.nix
index bd53a6f0b48a..2e267e2ef191 100644
--- a/pkgs/development/python-modules/apache-beam/default.nix
+++ b/pkgs/development/python-modules/apache-beam/default.nix
@@ -150,7 +150,7 @@ buildPythonPackage rec {
 
   # Make sure we're running the tests for the actually installed
   # package, so that cython's .so files are available.
-  preCheck = "cd $out/lib/${python.libPrefix}/site-packages";
+  preCheck = "cd $out/${python.sitePackages}";
 
   disabledTestPaths = [
     # Fails with
diff --git a/pkgs/development/python-modules/azure-common/default.nix b/pkgs/development/python-modules/azure-common/default.nix
index ed4cd5243abf..2b4caa102f79 100644
--- a/pkgs/development/python-modules/azure-common/default.nix
+++ b/pkgs/development/python-modules/azure-common/default.nix
@@ -25,7 +25,7 @@ buildPythonPackage rec {
   ] ++ lib.optionals (!isPy3k) [ setuptools ]; # need for namespace lookup
 
   postInstall = lib.optionalString (!isPy3k) ''
-    echo "__import__('pkg_resources').declare_namespace(__name__)" >> "$out/lib/${python.libPrefix}"/site-packages/azure/__init__.py
+    echo "__import__('pkg_resources').declare_namespace(__name__)" >> "$out/${python.sitePackages}"/azure/__init__.py
   '';
 
   doCheck = false;
diff --git a/pkgs/development/python-modules/azure-mgmt-common/default.nix b/pkgs/development/python-modules/azure-mgmt-common/default.nix
index 7ce7ce2c3f00..5f0390708c7d 100644
--- a/pkgs/development/python-modules/azure-mgmt-common/default.nix
+++ b/pkgs/development/python-modules/azure-mgmt-common/default.nix
@@ -28,8 +28,8 @@ buildPythonPackage rec {
   ];
 
   postInstall = pkgs.lib.optionalString (!isPy3k) ''
-    echo "__import__('pkg_resources').declare_namespace(__name__)" >> "$out/lib/${python.libPrefix}"/site-packages/azure/mgmt/__init__.py
-    echo "__import__('pkg_resources').declare_namespace(__name__)" >> "$out/lib/${python.libPrefix}"/site-packages/azure/__init__.py
+    echo "__import__('pkg_resources').declare_namespace(__name__)" >> "$out/${python.sitePackages}"/azure/mgmt/__init__.py
+    echo "__import__('pkg_resources').declare_namespace(__name__)" >> "$out/${python.sitePackages}"/azure/__init__.py
   '';
 
   doCheck = false;
diff --git a/pkgs/development/python-modules/backports-zoneinfo/default.nix b/pkgs/development/python-modules/backports-zoneinfo/default.nix
index ed0915eee522..ff5196855d34 100644
--- a/pkgs/development/python-modules/backports-zoneinfo/default.nix
+++ b/pkgs/development/python-modules/backports-zoneinfo/default.nix
@@ -46,7 +46,7 @@ buildPythonPackage rec {
     (substituteAll {
       name = "zoneinfo-path";
       src = ./zoneinfo.patch;
-      zoneinfo = "${tzdata}/lib/${python.libPrefix}/site-packages/tzdata/zoneinfo";
+      zoneinfo = "${tzdata}/${python.sitePackages}/tzdata/zoneinfo";
     })
   ];
 
diff --git a/pkgs/development/python-modules/distutils-cfg/default.nix b/pkgs/development/python-modules/distutils-cfg/default.nix
index cbf12c17582a..fb616c65d036 100644
--- a/pkgs/development/python-modules/distutils-cfg/default.nix
+++ b/pkgs/development/python-modules/distutils-cfg/default.nix
@@ -24,7 +24,7 @@ in stdenv.mkDerivation {
   dontUnpack = true;
 
   installPhase = ''
-    dest="$out/lib/${python.libPrefix}/site-packages/distutils"
+    dest="$out/${python.sitePackages}/distutils"
     mkdir -p $dest
     ln -s ${python}/lib/${python.libPrefix}/distutils/* $dest
     ln -s ${distutilsCfg} $dest/distutils.cfg
diff --git a/pkgs/development/python-modules/gruut-ipa/default.nix b/pkgs/development/python-modules/gruut-ipa/default.nix
index 26a7223b97e7..bca9611b7e21 100644
--- a/pkgs/development/python-modules/gruut-ipa/default.nix
+++ b/pkgs/development/python-modules/gruut-ipa/default.nix
@@ -22,7 +22,7 @@ buildPythonPackage rec {
   postPatch = ''
     patchShebangs bin/*
     substituteInPlace bin/speak-ipa \
-      --replace '${"\${src_dir}:"}' "$out/lib/${python.libPrefix}/site-packages:" \
+      --replace '${"\${src_dir}:"}' "$out/${python.sitePackages}:" \
       --replace "do espeak" "do ${espeak}/bin/espeak"
   '';
 
diff --git a/pkgs/development/python-modules/gurobipy/linux.nix b/pkgs/development/python-modules/gurobipy/linux.nix
index e9a72cbb5cba..a7c519406e74 100644
--- a/pkgs/development/python-modules/gurobipy/linux.nix
+++ b/pkgs/development/python-modules/gurobipy/linux.nix
@@ -16,7 +16,7 @@ buildPythonPackage {
 
   postFixup = ''
     patchelf --set-rpath $out/lib \
-      $out/lib/${python.libPrefix}/site-packages/gurobipy/gurobipy.so
+      $out/${python.sitePackages}/gurobipy/gurobipy.so
   '';
 
   meta = with lib; {
diff --git a/pkgs/development/python-modules/hg-commitsigs/default.nix b/pkgs/development/python-modules/hg-commitsigs/default.nix
index a97c2be2b98c..7a97bff33316 100644
--- a/pkgs/development/python-modules/hg-commitsigs/default.nix
+++ b/pkgs/development/python-modules/hg-commitsigs/default.nix
@@ -20,9 +20,9 @@ stdenv.mkDerivation rec {
   dontBuild = true;
 
   installPhase = ''
-    mkdir -p $out/lib/${python.libPrefix}/site-packages/hgext3rd/
+    mkdir -p $out/${python.sitePackages}/hgext3rd/
     install -D $src/commitsigs.py \
-               $out/lib/${python.libPrefix}/site-packages/hgext3rd/
+               $out/${python.sitePackages}/hgext3rd/
   '';
 
   meta = with lib; {
diff --git a/pkgs/development/python-modules/kaa-base/default.nix b/pkgs/development/python-modules/kaa-base/default.nix
index 96c83a4ac81d..8d83bdb5b110 100644
--- a/pkgs/development/python-modules/kaa-base/default.nix
+++ b/pkgs/development/python-modules/kaa-base/default.nix
@@ -24,20 +24,20 @@ buildPythonPackage rec {
   installPhase = ''
     runHook preInstall
 
-    mkdir -p "$out/lib/${python.libPrefix}/site-packages"
+    mkdir -p "$out/${python.sitePackages}"
 
-    export PYTHONPATH="$out/lib/${python.libPrefix}/site-packages:$PYTHONPATH"
+    export PYTHONPATH="$out/${python.sitePackages}:$PYTHONPATH"
 
     ${python}/bin/${python.executable} setup.py install \
-      --install-lib=$out/lib/${python.libPrefix}/site-packages \
+      --install-lib=$out/${python.sitePackages} \
       --prefix="$out"
 
-    eapth="$out/lib/${python.libPrefix}"/site-packages/easy-install.pth
+    eapth="$out/${python.sitePackages}/easy-install.pth"
     if [ -e "$eapth" ]; then
     mv "$eapth" $(dirname "$eapth")/${pname}-${version}.pth
     fi
 
-    rm -f "$out/lib/${python.libPrefix}"/site-packages/site.py*
+    rm -f "$out/${python.sitePackages}"/site.py*
 
     runHook postInstall
   '';
diff --git a/pkgs/development/python-modules/kaa-metadata/default.nix b/pkgs/development/python-modules/kaa-metadata/default.nix
index de71d207b876..20ae66f17a9d 100644
--- a/pkgs/development/python-modules/kaa-metadata/default.nix
+++ b/pkgs/development/python-modules/kaa-metadata/default.nix
@@ -29,20 +29,20 @@ buildPythonPackage rec {
   installPhase = ''
     runHook preInstall
 
-    mkdir -p "$out/lib/${python.libPrefix}/site-packages"
+    mkdir -p "$out/${python.sitePackages}"
 
-    export PYTHONPATH="$out/lib/${python.libPrefix}/site-packages:$PYTHONPATH"
+    export PYTHONPATH="$out/${python.sitePackages}:$PYTHONPATH"
 
     ${python}/bin/${python.executable} setup.py install \
-      --install-lib=$out/lib/${python.libPrefix}/site-packages \
+      --install-lib=$out/${python.sitePackages} \
       --prefix="$out"
 
-    eapth="$out/lib/${python.libPrefix}"/site-packages/easy-install.pth
+    eapth="$out/${python.sitePackages}/easy-install.pth"
     if [ -e "$eapth" ]; then
     mv "$eapth" $(dirname "$eapth")/${pname}-${version}.pth
     fi
 
-    rm -f "$out/lib/${python.libPrefix}"/site-packages/site.py*
+    rm -f "$out/${python.sitePackages}"/site.py*
 
     runHook postInstall
   '';
diff --git a/pkgs/development/python-modules/maestral/default.nix b/pkgs/development/python-modules/maestral/default.nix
index 3e871a90562b..4645174e122f 100644
--- a/pkgs/development/python-modules/maestral/default.nix
+++ b/pkgs/development/python-modules/maestral/default.nix
@@ -62,7 +62,7 @@ buildPythonPackage rec {
   makeWrapperArgs = [
     # Add the installed directories to the python path so the daemon can find them
     "--prefix PYTHONPATH : ${makePythonPath propagatedBuildInputs}"
-    "--prefix PYTHONPATH : $out/lib/${python.libPrefix}/site-packages"
+    "--prefix PYTHONPATH : $out/${python.sitePackages}"
   ];
 
   nativeCheckInputs = [
diff --git a/pkgs/development/python-modules/meep/default.nix b/pkgs/development/python-modules/meep/default.nix
index d99b5c3e2e0c..70a588f1c8aa 100644
--- a/pkgs/development/python-modules/meep/default.nix
+++ b/pkgs/development/python-modules/meep/default.nix
@@ -113,7 +113,7 @@ buildPythonPackage rec {
   checkPhase = ''
     runHook preCheck
 
-    export PYTHONPATH="$out/lib/${python.libPrefix}/site-packages:$PYTHONPATH"
+    export PYTHONPATH="$out/${python.sitePackages}:$PYTHONPATH"
 
     # Generate a python test script
     cat > test.py << EOF
diff --git a/pkgs/development/python-modules/mpi4py/default.nix b/pkgs/development/python-modules/mpi4py/default.nix
index f41519c00112..deb54ab149be 100644
--- a/pkgs/development/python-modules/mpi4py/default.nix
+++ b/pkgs/development/python-modules/mpi4py/default.nix
@@ -25,11 +25,11 @@ buildPythonPackage rec {
   configurePhase = "";
 
   installPhase = ''
-    mkdir -p "$out/lib/${python.libPrefix}/site-packages"
-    export PYTHONPATH="$out/lib/${python.libPrefix}/site-packages:$PYTHONPATH"
+    mkdir -p "$out/${python.sitePackages}"
+    export PYTHONPATH="$out/${python.sitePackages}:$PYTHONPATH"
 
     ${python}/bin/${python.executable} setup.py install \
-      --install-lib=$out/lib/${python.libPrefix}/site-packages \
+      --install-lib=$out/${python.sitePackages} \
       --prefix="$out"
 
     # --install-lib:
diff --git a/pkgs/development/python-modules/pmdarima/default.nix b/pkgs/development/python-modules/pmdarima/default.nix
index f1d152decc1f..2ddb03b8afe1 100644
--- a/pkgs/development/python-modules/pmdarima/default.nix
+++ b/pkgs/development/python-modules/pmdarima/default.nix
@@ -43,7 +43,7 @@ buildPythonPackage rec {
   # Make sure we're running the tests for the actually installed
   # package, so that cython's compiled files are available.
   preCheck = ''
-    cd $out/lib/${python.libPrefix}/site-packages
+    cd $out/${python.sitePackages}
   '';
 
   nativeCheckInputs = [ pytestCheckHook ];
diff --git a/pkgs/development/python-modules/pygmo/default.nix b/pkgs/development/python-modules/pygmo/default.nix
index 0ce6a2fd3f99..d311df0a4530 100644
--- a/pkgs/development/python-modules/pygmo/default.nix
+++ b/pkgs/development/python-modules/pygmo/default.nix
@@ -28,7 +28,7 @@ toPythonModule (stdenv.mkDerivation rec {
   };
 
   cmakeFlags = [
-    "-DPYGMO_INSTALL_PATH=${placeholder "out"}/lib/${python.libPrefix}/site-packages"
+    "-DPYGMO_INSTALL_PATH=${placeholder "out"}/${python.sitePackages}"
   ];
 
   nativeBuildInputs = [
diff --git a/pkgs/development/python-modules/rdkit/default.nix b/pkgs/development/python-modules/rdkit/default.nix
index 7d0632ebc836..de0bb15b8ce2 100644
--- a/pkgs/development/python-modules/rdkit/default.nix
+++ b/pkgs/development/python-modules/rdkit/default.nix
@@ -141,7 +141,7 @@ buildPythonPackage rec {
   checkPhase = ''
     export QT_QPA_PLATFORM='offscreen'
     export RDBASE=$(realpath ..)
-    export PYTHONPATH="$out/lib/${python.libPrefix}/site-packages:$PYTHONPATH"
+    export PYTHONPATH="$out/${python.sitePackages}:$PYTHONPATH"
     (cd $RDBASE/rdkit/Chem && python $RDBASE/rdkit/TestRunner.py test_list.py)
   '';
 
diff --git a/pkgs/development/python-modules/recursive-pth-loader/default.nix b/pkgs/development/python-modules/recursive-pth-loader/default.nix
index 499ad3c23d07..e42988eeff9a 100644
--- a/pkgs/development/python-modules/recursive-pth-loader/default.nix
+++ b/pkgs/development/python-modules/recursive-pth-loader/default.nix
@@ -14,7 +14,7 @@ stdenv.mkDerivation {
 
   installPhase =
     ''
-      dst=$out/lib/${python.libPrefix}/site-packages
+      dst=$out/${python.sitePackages}
       mkdir -p $dst
       cp sitecustomize.* $dst/
     '';
diff --git a/pkgs/development/python-modules/selenium/default.nix b/pkgs/development/python-modules/selenium/default.nix
index 5a5c4304c636..09ddebebe240 100644
--- a/pkgs/development/python-modules/selenium/default.nix
+++ b/pkgs/development/python-modules/selenium/default.nix
@@ -34,7 +34,7 @@ buildPythonPackage rec {
   '';
 
   postInstall = ''
-    DST_PREFIX=$out/lib/${python.libPrefix}/site-packages/selenium/webdriver/
+    DST_PREFIX=$out/${python.sitePackages}/selenium/webdriver/
     DST_REMOTE=$DST_PREFIX/remote/
     DST_FF=$DST_PREFIX/firefox
     cp ../rb/lib/selenium/webdriver/atoms/getAttribute.js $DST_REMOTE
diff --git a/pkgs/development/python2-modules/pygtk/default.nix b/pkgs/development/python2-modules/pygtk/default.nix
index c3960dd5309d..003474ee8582 100644
--- a/pkgs/development/python2-modules/pygtk/default.nix
+++ b/pkgs/development/python2-modules/pygtk/default.nix
@@ -64,8 +64,8 @@ buildPythonPackage rec {
   postInstall = ''
     rm $out/bin/pygtk-codegen-2.0
     ln -s ${pygobject2}/bin/pygobject-codegen-2.0  $out/bin/pygtk-codegen-2.0
-    ln -s ${pygobject2}/lib/${python.libPrefix}/site-packages/pygobject-${pygobject2.version}.pth \
-                  $out/lib/${python.libPrefix}/site-packages/${pname}-${version}.pth
+    ln -s ${pygobject2}/${python.sitePackages}/pygobject-${pygobject2.version}.pth \
+                  $out/${python.sitePackages}/${pname}-${version}.pth
   '';
 
   meta = with lib; {
diff --git a/pkgs/development/r-modules/default.nix b/pkgs/development/r-modules/default.nix
index 43d64f98639b..d39d0c5b8441 100644
--- a/pkgs/development/r-modules/default.nix
+++ b/pkgs/development/r-modules/default.nix
@@ -1304,7 +1304,7 @@ let
         substituteInPlace R/zzz.R \
           --replace ".onLoad <- function(...) {" \
             ".onLoad <- function(...) {
-          Sys.setenv(\"SPARK_HOME\" = Sys.getenv(\"SPARK_HOME\", unset = \"${pkgs.python3Packages.pyspark}/lib/${pkgs.python3Packages.python.libPrefix}/site-packages/pyspark\"))
+          Sys.setenv(\"SPARK_HOME\" = Sys.getenv(\"SPARK_HOME\", unset = \"${pkgs.python3Packages.pyspark}/${pkgs.python3Packages.python.sitePackages}/pyspark\"))
           Sys.setenv(\"JAVA_HOME\" = Sys.getenv(\"JAVA_HOME\", unset = \"${pkgs.jdk}\"))"
       '';
     });
diff --git a/pkgs/development/tools/postiats-utilities/default.nix b/pkgs/development/tools/postiats-utilities/default.nix
index 51d9d14efa17..6ac021e1ba09 100644
--- a/pkgs/development/tools/postiats-utilities/default.nix
+++ b/pkgs/development/tools/postiats-utilities/default.nix
@@ -26,7 +26,7 @@ stdenv.mkDerivation rec {
   '';
 
   installPhase = ''
-    libdir="$out/lib/${python3.libPrefix}/site-packages"
+    libdir="$out/${python3.sitePackages}"
     mkdir -p "$libdir"
     cp -r postiats "$libdir"
 
diff --git a/pkgs/servers/apache-airflow/python-package.nix b/pkgs/servers/apache-airflow/python-package.nix
index ac39c99ba7d1..29559cb60a31 100644
--- a/pkgs/servers/apache-airflow/python-package.nix
+++ b/pkgs/servers/apache-airflow/python-package.nix
@@ -265,7 +265,7 @@ buildPythonPackage rec {
   ];
 
   postInstall = ''
-    cp -rv ${airflow-frontend}/static/dist $out/lib/${python.libPrefix}/site-packages/airflow/www/static
+    cp -rv ${airflow-frontend}/static/dist $out/${python.sitePackages}/airflow/www/static
     # Needed for pythonImportsCheck below
     export HOME=$(mktemp -d)
   '';
diff --git a/pkgs/servers/baserow/default.nix b/pkgs/servers/baserow/default.nix
index ea46b4bfb8f2..37366183dba0 100644
--- a/pkgs/servers/baserow/default.nix
+++ b/pkgs/servers/baserow/default.nix
@@ -127,8 +127,8 @@ with python.pkgs; buildPythonApplication rec {
 
   fixupPhase = ''
     cp -r src/baserow/contrib/database/{api,action,trash,formula,file_import} \
-      $out/lib/${python.libPrefix}/site-packages/baserow/contrib/database/
-    cp -r src/baserow/core/management/backup $out/lib/${python.libPrefix}/site-packages/baserow/core/management/
+      $out/${python.sitePackages}/baserow/contrib/database/
+    cp -r src/baserow/core/management/backup $out/${python.sitePackages}/baserow/core/management/
   '';
 
   disabledTests = [
diff --git a/pkgs/servers/gpsd/default.nix b/pkgs/servers/gpsd/default.nix
index 662c4d530170..224ce41d185e 100644
--- a/pkgs/servers/gpsd/default.nix
+++ b/pkgs/servers/gpsd/default.nix
@@ -84,7 +84,7 @@ stdenv.mkDerivation rec {
     substituteInPlace SConscript --replace "env['CCVERSION']" "env['CC']"
 
     sconsFlags+=" udevdir=$out/lib/udev"
-    sconsFlags+=" python_libdir=$out/lib/${python3Packages.python.libPrefix}/site-packages"
+    sconsFlags+=" python_libdir=$out/${python3Packages.python.sitePackages}"
   '';
 
   # - leapfetch=no disables going online at build time to fetch leap-seconds
diff --git a/pkgs/tools/admin/gam/default.nix b/pkgs/tools/admin/gam/default.nix
index 6ea2b6c3da37..6cf340150ffb 100644
--- a/pkgs/tools/admin/gam/default.nix
+++ b/pkgs/tools/admin/gam/default.nix
@@ -52,8 +52,8 @@ python3.pkgs.buildPythonApplication rec {
     runHook preInstall
     mkdir -p $out/bin
     cp gam.py $out/bin/gam
-    mkdir -p $out/lib/${python3.libPrefix}/site-packages
-    cp -r gam $out/lib/${python3.libPrefix}/site-packages
+    mkdir -p $out/${python3.sitePackages}
+    cp -r gam $out/${python3.sitePackages}
     runHook postInstall
   '';
 
diff --git a/pkgs/tools/audio/tts/default.nix b/pkgs/tools/audio/tts/default.nix
index 48c936ca632f..d761e4605190 100644
--- a/pkgs/tools/audio/tts/default.nix
+++ b/pkgs/tools/audio/tts/default.nix
@@ -128,7 +128,7 @@ python.pkgs.buildPythonApplication rec {
 
     for file in $(grep -rl 'python TTS/bin' tests); do
       substituteInPlace "$file" \
-        --replace "python TTS/bin" "${python.interpreter} $out/lib/${python.libPrefix}/site-packages/TTS/bin"
+        --replace "python TTS/bin" "${python.interpreter} $out/${python.sitePackages}/TTS/bin"
     done
   '';
 
diff --git a/pkgs/tools/misc/debian-devscripts/default.nix b/pkgs/tools/misc/debian-devscripts/default.nix
index b8a58ff400e2..d70994753dbd 100644
--- a/pkgs/tools/misc/debian-devscripts/default.nix
+++ b/pkgs/tools/misc/debian-devscripts/default.nix
@@ -39,7 +39,7 @@ in stdenv.mkDerivation rec {
 
   preConfigure = ''
     export PERL5LIB="$PERL5LIB''${PERL5LIB:+:}${dpkg}";
-    tgtpy="$out/lib/${python.libPrefix}/site-packages"
+    tgtpy="$out/${python.sitePackages}"
     mkdir -p "$tgtpy"
     export PYTHONPATH="$PYTHONPATH''${PYTHONPATH:+:}$tgtpy"
     find lib po4a scripts -type f -exec sed -r \
diff --git a/pkgs/tools/security/arubaotp-seed-extractor/default.nix b/pkgs/tools/security/arubaotp-seed-extractor/default.nix
index a1ab0fd9f290..c2ffef83635d 100644
--- a/pkgs/tools/security/arubaotp-seed-extractor/default.nix
+++ b/pkgs/tools/security/arubaotp-seed-extractor/default.nix
@@ -28,7 +28,7 @@ python3Packages.buildPythonApplication {
   ];
 
   installPhase = ''
-    libdir="$out/lib/${python3Packages.python.libPrefix}/site-packages/arubaotp-seed-extractor"
+    libdir="$out/${python3Packages.python.sitePackages}/arubaotp-seed-extractor"
     mkdir -p "$libdir"
     cp scripts/* "$libdir"
     chmod +x "$libdir/main.py"
diff --git a/pkgs/tools/security/hash-slinger/default.nix b/pkgs/tools/security/hash-slinger/default.nix
index 0f0eeeb6b2af..cb02b806a986 100644
--- a/pkgs/tools/security/hash-slinger/default.nix
+++ b/pkgs/tools/security/hash-slinger/default.nix
@@ -49,7 +49,7 @@ stdenv.mkDerivation rec {
   '';
 
   installPhase = ''
-    mkdir -p $out/bin $out/man $out/lib/${python3.libPrefix}/site-packages
+    mkdir -p $out/bin $out/man $out/${python3.sitePackages}
     make install
     wrapPythonPrograms
   '';
diff --git a/pkgs/tools/security/pass/extensions/audit/default.nix b/pkgs/tools/security/pass/extensions/audit/default.nix
index 74e9dab46a7e..365f81759cce 100644
--- a/pkgs/tools/security/pass/extensions/audit/default.nix
+++ b/pkgs/tools/security/pass/extensions/audit/default.nix
@@ -41,7 +41,7 @@ in stdenv.mkDerivation rec {
   installFlags = [ "DESTDIR=${placeholder "out"}" "PREFIX=" ];
   postInstall = ''
     wrapProgram $out/lib/password-store/extensions/audit.bash \
-      --prefix PYTHONPATH : "$out/lib/${pythonEnv.libPrefix}/site-packages" \
+      --prefix PYTHONPATH : "$out/${pythonEnv.sitePackages}" \
       --run "export COMMAND"
   '';