diff --git a/pkgs/development/python-modules/pyvex/default.nix b/pkgs/development/python-modules/pyvex/default.nix
new file mode 100644
index 000000000000..ddec4f0f2397
--- /dev/null
+++ b/pkgs/development/python-modules/pyvex/default.nix
@@ -0,0 +1,39 @@
+{ lib
+, archinfo
+, bitstring
+, fetchPypi
+, cffi
+, buildPythonPackage
+, future
+, pycparser
+}:
+
+buildPythonPackage rec {
+  pname = "pyvex";
+  version = "9.0.5739";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "1jwxxw2kw7wkz7kh8m8vbavzw6m5k6xph7mazfn3k2qbsshh3lk3";
+  };
+
+  propagatedBuildInputs = [
+    archinfo
+    bitstring
+    cffi
+    future
+    pycparser
+  ];
+
+  # No tests are available on PyPI, GitHub release has tests
+  # Switch to GitHub release after all angr parts are present
+  doCheck = false;
+  pythonImportsCheck = [ "pyvex" ];
+
+  meta = with lib; {
+    description = "Python interface to libVEX and VEX IR";
+    homepage = "https://github.com/angr/pyvex";
+    license = with licenses; [ bsd2 gpl3Plus lgpl3Plus ];
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index eafc426858f5..eddaf6831f15 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -6520,6 +6520,8 @@ in {
 
   pyvera = callPackage ../development/python-modules/pyvera { };
 
+  pyvex = callPackage ../development/python-modules/pyvex { };
+
   pyviz-comms = callPackage ../development/python-modules/pyviz-comms { };
 
   pyvips = callPackage ../development/python-modules/pyvips {