diff --git a/pkgs/applications/misc/xiphos/0001-Add-dbus-glib-dependency-to-main.patch b/pkgs/applications/misc/xiphos/0001-Add-dbus-glib-dependency-to-main.patch
new file mode 100644
index 000000000000..71cb57ccef18
--- /dev/null
+++ b/pkgs/applications/misc/xiphos/0001-Add-dbus-glib-dependency-to-main.patch
@@ -0,0 +1,38 @@
+From 0e9e686c902935c0f00afdf9d0d45f9635995988 Mon Sep 17 00:00:00 2001
+From: Jan Tojnar <jtojnar@gmail.com>
+Date: Sat, 15 Jan 2022 05:00:37 +0100
+Subject: [PATCH] Add dbus-glib dependency to main
+
+It is required through the ipc header and the build will fail without it on Nix:
+
+	In file included from /build/source/src/main/search_sidebar.cc:48:
+	/build/source/src/gui/ipc.h:26:10: fatal error: dbus/dbus-glib.h: No such file or directory
+	   26 | #include <dbus/dbus-glib.h>
+	      |          ^~~~~~~~~~~~~~~~~~
+	compilation terminated.
+---
+ src/main/CMakeLists.txt | 11 +++++++++++
+ 1 file changed, 11 insertions(+)
+
+diff --git a/src/main/CMakeLists.txt b/src/main/CMakeLists.txt
+index 49b86371..bb8e4bb6 100644
+--- a/src/main/CMakeLists.txt
++++ b/src/main/CMakeLists.txt
+@@ -74,3 +74,14 @@ target_link_libraries(main
+   PkgConfig::Sword
+   PkgConfig::Biblesync
+   )
++
++IF (DBUS)
++  target_include_directories (main
++    PRIVATE ${CMAKE_CURRENT_BINARY_DIR}
++    PkgConfig::DBus
++    )
++  target_link_libraries(main
++    PRIVATE
++    PkgConfig::DBus
++    )
++ENDIF (DBUS)
+-- 
+2.34.1
+
diff --git a/pkgs/applications/misc/xiphos/default.nix b/pkgs/applications/misc/xiphos/default.nix
index 38349777edba..994127baca6d 100644
--- a/pkgs/applications/misc/xiphos/default.nix
+++ b/pkgs/applications/misc/xiphos/default.nix
@@ -3,47 +3,27 @@
 , fetchFromGitHub
 , fetchpatch
 , appstream-glib
-, at-spi2-core
 , biblesync
-, brotli
 , cmake
-, dbus
 , dbus-glib
 , desktop-file-utils
 , docbook2x
 , docbook_xml_dtd_412
-, enchant
-, gconf
+, enchant2
 , glib
-, gnome-doc-utils
-, gtk2
+, gtk3
 , gtkhtml
 , icu
 , intltool
 , isocodes
 , itstool
-, libdatrie
-, libepoxy
-, libglade
-, libgsf
-, libpsl
-, libselinux
-, libsepol
-, libsysprof-capture
-, libthai
 , libuuid
-, libxkbcommon
 , libxslt
 , minizip
-, pcre
 , pkg-config
-, python
-, scrollkeeper
-, sqlite
 , sword
 , webkitgtk
 , wrapGAppsHook
-, xorg
 , yelp-tools
 , zip
 }:
@@ -68,61 +48,44 @@ stdenv.mkDerivation rec {
       sha256 = "he3U7phU2/QCrZidHviupA7YwzudnQ9Jbb8eMZw6/ck=";
       extraPrefix = "";
     })
+
+    # Fix D-Bus build
+    # https://github.com/crosswire/xiphos/pull/1103
+    ./0001-Add-dbus-glib-dependency-to-main.patch
   ];
 
   nativeBuildInputs = [
     appstream-glib # for appstream-util
     cmake
     desktop-file-utils # for desktop-file-validate
+    docbook2x
+    docbook_xml_dtd_412
+    intltool
     itstool
+    libxslt
     pkg-config
     wrapGAppsHook
     yelp-tools # for yelp-build
+    zip # for building help epubs
   ];
 
   buildInputs = [
-    at-spi2-core
     biblesync
-    brotli
-    dbus
     dbus-glib
-    docbook2x
-    docbook_xml_dtd_412
-    enchant
-    gconf
+    enchant2
     glib
-    gnome-doc-utils
-    gtk2
+    gtk3
     gtkhtml
     icu
-    intltool
     isocodes
-    libdatrie
-    libepoxy
-    libglade
-    libgsf
-    libpsl
-    libselinux
-    libsepol
-    libsysprof-capture
-    libthai
     libuuid
-    libxkbcommon
-    libxslt
     minizip
-    pcre
-    python
-    scrollkeeper
-    sqlite
     sword
     webkitgtk
-    xorg.libXdmcp
-    xorg.libXtst
-    zip
   ];
 
   cmakeFlags = [
-    "-DDBUS=OFF"
+    # WebKit-based editor does not build.
     "-DGTKHTML=ON"
   ];
 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 8bebf6697029..ccbbcfc78b30 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -29748,11 +29748,7 @@ with pkgs;
   };
 
   xiphos = callPackage ../applications/misc/xiphos {
-    gconf = gnome2.GConf;
-    inherit (gnome2) libglade scrollkeeper;
     gtkhtml = gnome2.gtkhtml4;
-    python = python27;
-    enchant = enchant2;
   };
 
   xournal = callPackage ../applications/graphics/xournal {