diff --git a/pkgs/development/libraries/google-gflags/default.nix b/pkgs/development/libraries/google-gflags/default.nix
index 0f089d16eadd..1a3a16587274 100644
--- a/pkgs/development/libraries/google-gflags/default.nix
+++ b/pkgs/development/libraries/google-gflags/default.nix
@@ -13,6 +13,9 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ cmake ];
 
+  # This isn't used by the build and breaks the CMake build on case-insensitive filesystems (e.g., on Darwin)
+  preConfigure = "rm BUILD";
+
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=ON"
     "-DBUILD_STATIC_LIBS=ON"