diff --git a/pkgs/misc/emulators/pcsx2/default.nix b/pkgs/misc/emulators/pcsx2/default.nix
index 13d2ea74f342..4246240463ee 100644
--- a/pkgs/misc/emulators/pcsx2/default.nix
+++ b/pkgs/misc/emulators/pcsx2/default.nix
@@ -2,7 +2,6 @@
 , cmake
 , fetchFromGitHub
 , fmt
-, gcc-unwrapped
 , gettext
 , glib
 , gtk3
@@ -13,7 +12,6 @@
 , libpulseaudio
 , libsamplerate
 , libxml2
-, makeWrapper
 , perl
 , pkg-config
 , portaudio
@@ -28,47 +26,24 @@
 
 stdenv.mkDerivation {
   pname = "pcsx2";
-  version = "unstable-2020-11-13";
+  version = "unstable-2021-10-28";
 
   src = fetchFromGitHub {
     owner = "PCSX2";
     repo = "pcsx2";
     fetchSubmodules = true;
-    rev = "319287dbe552c8405720b25dfdf5fa518deeee0b";
-    sha256 = "1kswc8vw9hbv2nigp8cxrgf2s0ik7p4i203cbqci8zjmnkaqpsai";
+    rev = "52eab493591137d830b45337e04c75ff525a31f9";
+    sha256 = "RhAo5Fob8G16jzb9MOAS43vwTkFzf5XupymN0dzeGJU=";
   };
 
   cmakeFlags = [
-    "-DCMAKE_INSTALL_PREFIX=${placeholder "out"}"
     "-DDISABLE_ADVANCE_SIMD=TRUE"
     "-DDISABLE_PCSX2_WRAPPER=TRUE"
-    "-DDOC_DIR=${placeholder "out"}/share/doc/pcsx2"
-    "-DGAMEINDEX_DIR=${placeholder "out"}/share/pcsx2"
-    "-DGLSL_SHADER_DIR=${placeholder "out"}/share/pcsx2"
-    "-DGTK3_API=TRUE"
     "-DPACKAGE_MODE=TRUE"
-    "-DPLUGIN_DIR=${placeholder "out"}/lib/pcsx2"
-    "-DREBUILD_SHADER=TRUE"
-    "-DUSE_LTO=TRUE"
-    "-DwxWidgets_CONFIG_EXECUTABLE=${wxGTK}/bin/wx-config"
-    "-DwxWidgets_INCLUDE_DIRS=${wxGTK}/include"
-    "-DwxWidgets_LIBRARIES=${wxGTK}/lib"
     "-DXDG_STD=TRUE"
   ];
 
-  postPatch = ''
-    substituteInPlace cmake/BuildParameters.cmake \
-      --replace /usr/bin/gcc-ar ${gcc-unwrapped}/bin/gcc-ar \
-      --replace /usr/bin/gcc-nm ${gcc-unwrapped}/bin/gcc-nm \
-      --replace /usr/bin/gcc-ranlib ${gcc-unwrapped}/bin/gcc-ranlib
-  '';
-
-  postFixup = ''
-    wrapProgram $out/bin/PCSX2 \
-      --set __GL_THREADED_OPTIMIZATIONS 1
-  '';
-
-  nativeBuildInputs = [ cmake makeWrapper perl pkg-config wrapGAppsHook ];
+  nativeBuildInputs = [ cmake perl pkg-config wrapGAppsHook ];
 
   buildInputs = [
     alsa-lib