diff --git a/pkgs/development/python-modules/cx_oracle/0001-odpi-src-dpiOci.c-nixify-libclntsh.so-dlopen.patch b/pkgs/development/python-modules/cx_oracle/0001-odpi-src-dpiOci.c-nixify-libclntsh.so-dlopen.patch
new file mode 100644
index 000000000000..a2de7b248531
--- /dev/null
+++ b/pkgs/development/python-modules/cx_oracle/0001-odpi-src-dpiOci.c-nixify-libclntsh.so-dlopen.patch
@@ -0,0 +1,27 @@
+From 355b9d812efdfbd041e14b365258b69c81689981 Mon Sep 17 00:00:00 2001
+From: Florian Klink <flokli@flokli.de>
+Date: Thu, 17 May 2018 18:37:40 +0200
+Subject: [PATCH] odpi/src/dpiOci.c: nixify libclntsh.so dlopen
+
+---
+ odpi/src/dpiOci.c | 4 ++++
+ 1 file changed, 4 insertions(+)
+
+diff --git a/odpi/src/dpiOci.c b/odpi/src/dpiOci.c
+index 76b9867..22c2987 100644
+--- a/odpi/src/dpiOci.c
++++ b/odpi/src/dpiOci.c
+@@ -1575,6 +1575,10 @@ static int dpiOci__loadLib(dpiError *error)
+             }
+         }
+     }
++    if(!dpiOciLibHandle) {
++        dpiOciLibHandle = dlopen("@libclntsh@", RTLD_LAZY);
++    }
++
+ #endif
+ 
+     if (!dpiOciLibHandle) {
+-- 
+2.16.3
+
diff --git a/pkgs/development/python-modules/cx_oracle/default.nix b/pkgs/development/python-modules/cx_oracle/default.nix
index 637518b1969b..c9925fad88d4 100644
--- a/pkgs/development/python-modules/cx_oracle/default.nix
+++ b/pkgs/development/python-modules/cx_oracle/default.nix
@@ -13,6 +13,12 @@ buildPythonPackage rec {
     sha256 = "0200j6jh80rpgzxmvgcxmkshaj4zadq32g2i97nlwiq3f7q374l7";
   };
 
+  patches = [ ./0001-odpi-src-dpiOci.c-nixify-libclntsh.so-dlopen.patch ];
+
+  postPatch = ''
+    substituteInPlace odpi/src/dpiOci.c --replace @libclntsh@ ${oracle-instantclient}/lib/libclntsh.so";
+  '';
+
   # Check need an Oracle database to run
   doCheck = false;