diff --git a/pkgs/tools/misc/man-db/default.nix b/pkgs/tools/misc/man-db/default.nix
index 9a0164cf7949..df1a2daddb91 100644
--- a/pkgs/tools/misc/man-db/default.nix
+++ b/pkgs/tools/misc/man-db/default.nix
@@ -38,6 +38,10 @@ stdenv.mkDerivation rec {
     "--with-config-file=${placeholder "out"}/etc/man_db.conf"
     "--with-systemdtmpfilesdir=${placeholder "out"}/lib/tmpfiles.d"
     "--with-systemdsystemunitdir=${placeholder "out"}/lib/systemd/system"
+  ] ++ stdenv.lib.optional stdenv.hostPlatform.isDarwin [
+    "ac_cv_func__set_invalid_parameter_handler=no"
+    "ac_cv_func_posix_fadvise=no"
+    "ac_cv_func_mempcpy=no"
   ];
 
   preConfigure = ''
@@ -67,7 +71,7 @@ stdenv.mkDerivation rec {
 
   enableParallelBuilding = true;
 
-  doCheck = !stdenv.hostPlatform.isMusl; /* iconv binary */
+  doCheck = !stdenv.hostPlatform.isMusl /* iconv binary */ && !stdenv.hostPlatform.isDarwin;
 
   meta = with stdenv.lib; {
     homepage = http://man-db.nongnu.org;