diff --git a/pkgs/applications/science/robotics/mavproxy/default.nix b/pkgs/applications/science/robotics/mavproxy/default.nix
index 8e7c5bddd961..22a32f89bded 100644
--- a/pkgs/applications/science/robotics/mavproxy/default.nix
+++ b/pkgs/applications/science/robotics/mavproxy/default.nix
@@ -1,5 +1,5 @@
-{ lib, buildPythonApplication, fetchPypi, matplotlib, numpy, pymavlink, pyserial
-, setuptools, wxPython_4_0 }:
+{ stdenv, lib, buildPythonApplication, fetchPypi, matplotlib, numpy, pymavlink, pyserial
+, setuptools, wxPython_4_0, billiard, gnureadline }:
 
 buildPythonApplication rec {
   pname = "MAVProxy";
@@ -10,6 +10,11 @@ buildPythonApplication rec {
     sha256 = "fe046481b793b592334749249620fce8a463f4c46b394ff744645975465d677b";
   };
 
+  postPatch = ''
+    substituteInPlace setup.py \
+      --replace "opencv-python" ""
+  '';
+
   propagatedBuildInputs = [
     matplotlib
     numpy
@@ -17,7 +22,7 @@ buildPythonApplication rec {
     pyserial
     setuptools
     wxPython_4_0
-  ];
+  ] ++ lib.optionals stdenv.isDarwin [ billiard gnureadline ];
 
   # No tests
   doCheck = false;
diff --git a/pkgs/development/libraries/wxwidgets/3.0/mac.nix b/pkgs/development/libraries/wxwidgets/3.0/mac.nix
index 1b4c67024515..a6973f53de8f 100644
--- a/pkgs/development/libraries/wxwidgets/3.0/mac.nix
+++ b/pkgs/development/libraries/wxwidgets/3.0/mac.nix
@@ -1,11 +1,11 @@
 { stdenv, fetchzip, expat, libiconv, libjpeg, libpng, libtiff, zlib
 # darwin only attributes
 , derez, rez, setfile
-, AGL, Cocoa, Kernel
+, AGL, Cocoa, Kernel, WebKit
 }:
 
 stdenv.mkDerivation rec {
-  version = "3.0.4";
+  version = "3.0.5.1";
   pname = "wxmac";
 
   src = fetchzip {
@@ -16,7 +16,7 @@ stdenv.mkDerivation rec {
   buildInputs = [
     expat libiconv libjpeg libpng libtiff zlib
     derez rez setfile
-    AGL Cocoa Kernel
+    AGL Cocoa Kernel WebKit
   ];
 
   postPatch = ''
diff --git a/pkgs/development/python-modules/wxPython/4.0.nix b/pkgs/development/python-modules/wxPython/4.0.nix
index 406493362c46..a1cee317e345 100644
--- a/pkgs/development/python-modules/wxPython/4.0.nix
+++ b/pkgs/development/python-modules/wxPython/4.0.nix
@@ -9,10 +9,18 @@
 , python
 , doxygen
 , ncurses
-, wxGTK
+, libintl
 , numpy
 , pillow
 , six
+, wxGTK
+, wxmac
+, IOKit
+, Carbon
+, Cocoa
+, AudioToolbox
+, OpenGL
+, CoreFoundation
 }:
 
 buildPythonPackage rec {
@@ -26,8 +34,16 @@ buildPythonPackage rec {
 
   doCheck = false;
 
-  nativeBuildInputs = [ pkgconfig which doxygen wxGTK ];
-  buildInputs = [ ncurses wxGTK.gtk ];
+  nativeBuildInputs = [ pkgconfig which doxygen ]
+  ++ (if stdenv.isDarwin then [ wxmac ] else [ wxGTK ]);
+
+  buildInputs = [ ncurses libintl ]
+  ++ (if stdenv.isDarwin
+  then
+    [ AudioToolbox Carbon Cocoa CoreFoundation IOKit OpenGL ]
+  else
+    [ wxGTK.gtk ]
+  );
 
   DOXYGEN = "${doxygen}/bin/doxygen";
 
@@ -50,7 +66,7 @@ buildPythonPackage rec {
     ${python.interpreter} setup.py install --skip-build --prefix=$out
   '';
 
-  passthru = { inherit wxGTK; };
+  passthru = { wxWidgets = if stdenv.isDarwin then wxmac else wxGTK; };
 
 
   meta = {
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 8c19c41a4e35..79c93abe86f5 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -17090,7 +17090,7 @@ in
   };
 
   wxmac = callPackage ../development/libraries/wxwidgets/3.0/mac.nix {
-    inherit (darwin.apple_sdk.frameworks) AGL Cocoa Kernel;
+    inherit (darwin.apple_sdk.frameworks) AGL Cocoa Kernel WebKit;
     inherit (darwin.stubs) setfile rez derez;
   };
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f902e97dbc39..b56d493df39b 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8143,6 +8143,7 @@ in {
 
   wxPython_4_0 = callPackage ../development/python-modules/wxPython/4.0.nix {
     inherit (pkgs) pkgconfig;
+    inherit (pkgs.darwin.apple_sdk.frameworks) AudioToolbox Carbon Cocoa CoreFoundation IOKit OpenGL;
     wxGTK = pkgs.wxGTK30.override {
       withGtk2 = false;
       withWebKit = true;