diff --git a/pkgs/development/libraries/wxGTK-2.9/default.nix b/pkgs/development/libraries/wxGTK-2.9/default.nix
index fca5a4a278e0..e8a661a33892 100644
--- a/pkgs/development/libraries/wxGTK-2.9/default.nix
+++ b/pkgs/development/libraries/wxGTK-2.9/default.nix
@@ -1,5 +1,5 @@
 { stdenv, fetchurl, pkgconfig, gtk, libXinerama, libSM, libXxf86vm, xf86vidmodeproto
-, gstreamer, gst_plugins_base, GConf
+, gstreamer, gst_plugins_base, GConf, setFile
 , withMesa ? true, mesa ? null, compat24 ? false, compat26 ? true, unicode ? true,
 }:
 
@@ -18,19 +18,23 @@ stdenv.mkDerivation {
     sha256 = "04jda4bns7cmp7xy68qz112yg0lribpc6xs5k9gilfqcyhshqlvc";
   };
 
-  buildInputs = [ gtk libXinerama libSM libXxf86vm xf86vidmodeproto gstreamer gst_plugins_base GConf ]
-    ++ optional withMesa mesa;
+  buildInputs =
+    [ gtk libXinerama libSM libXxf86vm xf86vidmodeproto gstreamer
+      gst_plugins_base GConf ]
+    ++ optional withMesa mesa
+    ++ optional stdenv.isDarwin setFile;
 
   nativeBuildInputs = [ pkgconfig ];
 
-  configureFlags = [
-    "--enable-gtk2"
-    (if compat24 then "--enable-compat24" else "--disable-compat24")
-    (if compat26 then "--enable-compat26" else "--disable-compat26")
-    "--disable-precomp-headers"
-    (if unicode then "--enable-unicode" else "")
-    "--enable-mediactrl"
-  ] ++ optional withMesa "--with-opengl";
+  configureFlags =
+    [ "--enable-gtk2" "--disable-precomp-headers" "--enable-mediactrl"
+      (if compat24 then "--enable-compat24" else "--disable-compat24")
+      (if compat26 then "--enable-compat26" else "--disable-compat26") ]
+    ++ optional unicode "--enable-unicode"
+    ++ optional withMesa "--with-opengl"
+    ++ optionals stdenv.isDarwin
+      # allow building on 64-bit
+      [ "--with-cocoa" "--enable-universal-binaries" ];
 
   SEARCH_LIB = optionalString withMesa "${mesa}/lib";
 
@@ -38,7 +42,11 @@ stdenv.mkDerivation {
     substituteInPlace configure --replace 'SEARCH_INCLUDE=' 'DUMMY_SEARCH_INCLUDE='
     substituteInPlace configure --replace 'SEARCH_LIB=' 'DUMMY_SEARCH_LIB='
     substituteInPlace configure --replace /usr /no-such-path
-  ";
+  " + optionalString stdenv.isDarwin ''
+    substituteInPlace configure --replace \
+      'ac_cv_prog_SETFILE="/Developer/Tools/SetFile"' \
+      'ac_cv_prog_SETFILE="${setFile}/bin/SetFile"'
+  '';
 
   postInstall = "
     (cd $out/include && ln -s wx-*/* .)
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 8bbe1e14cca9..c584c195c79f 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -5475,6 +5475,11 @@ let
   wxGTK29 = callPackage ../development/libraries/wxGTK-2.9/default.nix {
     inherit (gnome) GConf;
     withMesa = lib.elem system lib.platforms.mesaPlatforms;
+
+    # use for Objective-C++ compiler
+    stdenv = if stdenv.isDarwin
+      then clangStdenv
+      else stdenv;
   };
 
   wtk = callPackage ../development/libraries/wtk { };