diff --git a/pkgs/development/compilers/mlton/default.nix b/pkgs/development/compilers/mlton/default.nix
index 9c5ce109b86b..583f6f80137f 100644
--- a/pkgs/development/compilers/mlton/default.nix
+++ b/pkgs/development/compilers/mlton/default.nix
@@ -63,6 +63,8 @@ stdenv.mkDerivation rec {
     substituteInPlace $(pwd)/../${usr_prefix}/bin/mlton --replace '/${usr_prefix}/lib/mlton' $(pwd)/../${usr_prefix}/lib/mlton
   '' + stdenv.lib.optionalString stdenv.cc.isClang ''
     sed -i "s_	patch -s -p0 <gdtoa.hide-public-fns.patch_	patch -s -p0 <gdtoa.hide-public-fns.patch\n\tsed -i 's|printf(emptyfmt|printf(\"\"|g' ./gdtoa/arithchk.c_" ./runtime/Makefile
+  '' + stdenv.lib.optionalString stdenv.isDarwin ''
+    sed -i 's|XCFLAGS += -I/usr/local/include -I/sw/include -I/opt/local/include||' ./runtime/Makefile
   '';
 
   preBuild = ''
@@ -83,6 +85,11 @@ stdenv.mkDerivation rec {
     for e in mllex mlyacc ; do
       patchelf --set-interpreter ${dynamic_linker} $(pwd)/../${usr_prefix}/bin/$e
     done
+  '' + stdenv.lib.optionalString stdenv.isDarwin ''
+    # Patch libgmp linking
+    install_name_tool -change /opt/local/lib/libgmp.10.dylib ${gmp}/lib/libgmp.10.dylib $(pwd)/../${usr_prefix}/lib/mlton/mlton-compile
+    install_name_tool -change /opt/local/lib/libgmp.10.dylib ${gmp}/lib/libgmp.10.dylib $(pwd)/../${usr_prefix}/bin/mlyacc
+    install_name_tool -change /opt/local/lib/libgmp.10.dylib ${gmp}/lib/libgmp.10.dylib $(pwd)/../${usr_prefix}/bin/mllex
   '';
 
   doCheck = true;