diff --git a/pkgs/development/compilers/llvm/git/compiler-rt/darwin-targetconditionals.patch b/pkgs/development/compilers/llvm/git/compiler-rt/darwin-targetconditionals.patch
new file mode 100644
index 000000000000..425dc2af01e7
--- /dev/null
+++ b/pkgs/development/compilers/llvm/git/compiler-rt/darwin-targetconditionals.patch
@@ -0,0 +1,71 @@
+diff --git a/lib/sanitizer_common/sanitizer_mac.cpp b/lib/sanitizer_common/sanitizer_mac.cpp
+--- a/lib/sanitizer_common/sanitizer_mac.cpp
++++ b/lib/sanitizer_common/sanitizer_mac.cpp
+@@ -613,9 +613,15 @@ HandleSignalMode GetHandleSignalMode(int signum) {
+ // Offset example:
+ // XNU 17 -- macOS 10.13 -- iOS 11 -- tvOS 11 -- watchOS 4
+ constexpr u16 GetOSMajorKernelOffset() {
+-  if (TARGET_OS_OSX) return 4;
+-  if (TARGET_OS_IOS || TARGET_OS_TV) return 6;
+-  if (TARGET_OS_WATCH) return 13;
++#if TARGET_OS_OSX
++  return 4;
++#endif
++#if TARGET_OS_IOS || TARGET_OS_TV
++  return 6;
++#endif
++#if TARGET_OS_WATCH
++  return 13;
++#endif
+ }
+ 
+ using VersStr = char[64];
+@@ -627,13 +633,13 @@ static uptr ApproximateOSVersionViaKernelVersion(VersStr vers) {
+   u16 os_major = kernel_major - offset;
+ 
+   const char *format = "%d.0";
+-  if (TARGET_OS_OSX) {
+-    if (os_major >= 16) {  // macOS 11+
+-      os_major -= 5;
+-    } else {  // macOS 10.15 and below
+-      format = "10.%d";
+-    }
++#if TARGET_OS_OSX
++  if (os_major >= 16) {  // macOS 11+
++    os_major -= 5;
++  } else {  // macOS 10.15 and below
++    format = "10.%d";
+   }
++#endif
+   return internal_snprintf(vers, sizeof(VersStr), format, os_major);
+ }
+ 
+@@ -681,15 +687,14 @@ void ParseVersion(const char *vers, u16 *major, u16 *minor) {
+ // Aligned versions example:
+ // macOS 10.15 -- iOS 13 -- tvOS 13 -- watchOS 6
+ static void MapToMacos(u16 *major, u16 *minor) {
+-  if (TARGET_OS_OSX)
+-    return;
+-
+-  if (TARGET_OS_IOS || TARGET_OS_TV)
++#if !TARGET_OS_OSX
++#if TARGET_OS_IOS || TARGET_OS_TV
+     *major += 2;
+-  else if (TARGET_OS_WATCH)
++#elif TARGET_OS_WATCH
+     *major += 9;
+-  else
++#else
+     UNREACHABLE("unsupported platform");
++#endif
+ 
+   if (*major >= 16) {  // macOS 11+
+     *major -= 5;
+@@ -697,6 +702,7 @@ static void MapToMacos(u16 *major, u16 *minor) {
+     *minor = *major;
+     *major = 10;
+   }
++#endif
+ }
+ 
+ static MacosVersion GetMacosAlignedVersionInternal() {
diff --git a/pkgs/development/compilers/llvm/git/compiler-rt/default.nix b/pkgs/development/compilers/llvm/git/compiler-rt/default.nix
index 8e258e349b9d..eb3446342b4a 100644
--- a/pkgs/development/compilers/llvm/git/compiler-rt/default.nix
+++ b/pkgs/development/compilers/llvm/git/compiler-rt/default.nix
@@ -60,6 +60,8 @@ stdenv.mkDerivation {
     # extra `/`.
     ./normalize-var.patch
   ]# ++ lib.optional stdenv.hostPlatform.isMusl ./sanitizers-nongnu.patch
+    # Prevent a compilation error on darwin
+    ++ lib.optional stdenv.hostPlatform.isDarwin ./darwin-targetconditionals.patch
     ++ lib.optional stdenv.hostPlatform.isAarch32 ./armv7l.patch;
 
   # TSAN requires XPC on Darwin, which we have no public/free source files for. We can depend on the Apple frameworks