diff --git a/pkgs/development/libraries/libusb1/default.nix b/pkgs/development/libraries/libusb1/default.nix
index 19a8025359a0..9a08a7756c84 100644
--- a/pkgs/development/libraries/libusb1/default.nix
+++ b/pkgs/development/libraries/libusb1/default.nix
@@ -1,4 +1,14 @@
-{ stdenv, fetchurl, pkgconfig, systemd ? null, libobjc, IOKit, withStatic ? false }:
+{ stdenv
+, fetchurl
+, pkgconfig
+, enableSystemd ? stdenv.isLinux && !stdenv.hostPlatform.isMusl
+, systemd ? null
+, libobjc
+, IOKit
+, withStatic ? false
+}:
+
+assert enableSystemd -> systemd != null;
 
 stdenv.mkDerivation (rec {
   pname = "libusb";
@@ -13,12 +23,17 @@ stdenv.mkDerivation (rec {
 
   nativeBuildInputs = [ pkgconfig ];
   propagatedBuildInputs =
-    stdenv.lib.optional stdenv.isLinux systemd ++
+    stdenv.lib.optional enableSystemd systemd ++
     stdenv.lib.optionals stdenv.isDarwin [ libobjc IOKit ];
 
   NIX_LDFLAGS = stdenv.lib.optionalString stdenv.isLinux "-lgcc_s";
 
-  preFixup = stdenv.lib.optionalString stdenv.isLinux ''
+  configureFlags =
+    # We use `isLinux` here only to avoid mass rebuilds for Darwin, where
+    # disabling udev happens automatically. Remove `isLinux` at next big change!
+    stdenv.lib.optional (stdenv.isLinux && !enableSystemd) "--disable-udev";
+
+  preFixup = stdenv.lib.optionalString enableSystemd ''
     sed 's,-ludev,-L${systemd.lib}/lib -ludev,' -i $out/lib/libusb-1.0.la
   '';