diff --git a/pkgs/applications/networking/mailreaders/mailpile/default.nix b/pkgs/applications/networking/mailreaders/mailpile/default.nix
index 1e68d2e90b8d..2b1e9fc4fb34 100644
--- a/pkgs/applications/networking/mailreaders/mailpile/default.nix
+++ b/pkgs/applications/networking/mailreaders/mailpile/default.nix
@@ -10,7 +10,7 @@ buildPythonPackage rec {
   };
 
   propagatedBuildInputs = with pythonPackages; [
-    pillow jinja2 spambayes pythonPackages."lxml-2.3.6" python.modules.readline or null];
+    pillow jinja2 spambayes pythonPackages.lxml python.modules.readline or null];
 
   meta = with stdenv.lib; {
     description = "A modern, fast web-mail client with user-friendly encryption and privacy features";
diff --git a/pkgs/development/python-modules/dbus/default.nix b/pkgs/development/python-modules/dbus/default.nix
index d88504379ed0..bc386e7e5ac2 100644
--- a/pkgs/development/python-modules/dbus/default.nix
+++ b/pkgs/development/python-modules/dbus/default.nix
@@ -1,6 +1,6 @@
-{ stdenv, fetchurl, python, pkgconfig, dbus, dbus_glib, dbus_tools }:
+{ stdenv, fetchurl, python, pkgconfig, dbus, dbus_glib, dbus_tools, isPyPy }:
 
-stdenv.mkDerivation rec {
+if isPyPy then throw "dbus-python not supported for interpreter ${python.executable}" else stdenv.mkDerivation rec {
   name = "dbus-python-1.2.0";
 
   src = fetchurl {
diff --git a/pkgs/development/python-modules/wxPython/2.8.nix b/pkgs/development/python-modules/wxPython/2.8.nix
index 8819605528d6..64dd59242c2d 100644
--- a/pkgs/development/python-modules/wxPython/2.8.nix
+++ b/pkgs/development/python-modules/wxPython/2.8.nix
@@ -1,10 +1,10 @@
-{ stdenv, fetchurl, pkgconfig, wxGTK, pythonPackages }:
+{ stdenv, fetchurl, pkgconfig, wxGTK, pythonPackages, python, isPyPy }:
 
 assert wxGTK.unicode;
 
 let version = "2.8.12.1"; in
 
-stdenv.mkDerivation {
+if isPyPy then throw "wxPython-${version} not supported for interpreter ${python.executable}" else stdenv.mkDerivation {
   name = "wxPython-${version}";
   
   builder = ./builder.sh;
diff --git a/pkgs/development/python-modules/wxPython/3.0.nix b/pkgs/development/python-modules/wxPython/3.0.nix
index 9aa6148643bd..4f89dbeb4105 100644
--- a/pkgs/development/python-modules/wxPython/3.0.nix
+++ b/pkgs/development/python-modules/wxPython/3.0.nix
@@ -1,4 +1,4 @@
-{ stdenv, fetchurl, pkgconfig, wxGTK, pythonPackages, openglSupport ? true }:
+{ stdenv, fetchurl, pkgconfig, wxGTK, pythonPackages, openglSupport ? true, python, isPyPy }:
 
 assert wxGTK.unicode;
 
@@ -6,7 +6,7 @@ with stdenv.lib;
 
 let version = "3.0.0.0"; in
 
-stdenv.mkDerivation {
+if isPyPy then throw "wxPython-${version} not supported for interpreter ${python.executable}" else stdenv.mkDerivation {
   name = "wxPython-${version}";
   
   builder = ./builder3.0.sh;
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 712c64319db0..6afdf28643c6 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -65,7 +65,7 @@ rec {
 
   dbus = import ../development/python-modules/dbus {
     inherit (pkgs) stdenv fetchurl pkgconfig dbus dbus_glib dbus_tools;
-    inherit python;
+    inherit python isPyPy;
   };
 
   discid = buildPythonPackage rec {
@@ -4118,6 +4118,7 @@ rec {
     name = "httpretty-${version}";
     version = "0.8.3";
     disabled = isPy3k;
+    doCheck = !isPyPy;
 
     src = fetchurl {
       url = "http://pypi.python.org/packages/source/h/httpretty/${name}.tar.gz";
@@ -4230,6 +4231,7 @@ rec {
 
   ipdb = buildPythonPackage rec {
     name = "ipdb-0.8";
+    disabled = isPyPy;  # setupterm: could not find terminfo database
     src = fetchurl {
       url = "http://pypi.python.org/packages/source/i/ipdb/${name}.zip";
       md5 = "96dca0712efa01aa5eaf6b22071dd3ed";
@@ -4442,23 +4444,6 @@ rec {
     propagatedBuildInputs = [ unittest2 ];
   };
 
-  "lxml-2.3.6" = buildPythonPackage rec {
-    name = "lxml-2.3.6";
-    src = fetchurl {
-      url = "http://pypi.python.org/packages/source/l/lxml/lxml-2.3.6.tar.gz";
-      md5 = "d5d886088e78b1bdbfd66d328fc2d0bc";
-    };
-    buildInputs = [ pkgs.libxml2 pkgs.libxslt ];
-    propagatedBuildInputs = [  ];
-    doCheck = false;
-
-    meta = {
-      description = "Pythonic binding for the libxml2 and libxslt libraries";
-      homepage = http://codespeak.net/lxml/index.html;
-      license = "BSD";
-    };
-  };
-
   lxml = buildPythonPackage ( rec {
     name = "lxml-3.3.6";
 
@@ -5449,6 +5434,7 @@ rec {
   livestreamer = buildPythonPackage rec {
     version = "1.10.2";
     name = "livestreamer-${version}";
+    disabled = isPyPy;
 
     src = fetchurl {
       url = "https://github.com/chrippa/livestreamer/archive/v${version}.tar.gz";
@@ -8238,6 +8224,7 @@ rec {
   sqlalchemy = sqlalchemy9.override rec {
     name = "SQLAlchemy-0.7.10";
     disabled = isPy34;
+    doCheck = !isPyPy;
 
     src = fetchurl {
       url = "http://pypi.python.org/packages/source/S/SQLAlchemy/${name}.tar.gz";
@@ -8256,6 +8243,7 @@ rec {
   sqlalchemy8 = sqlalchemy9.override rec {
     name = "SQLAlchemy-0.8.7";
     disabled = isPy34;
+    doCheck = !isPyPy;
 
     src = fetchurl {
       url = "https://pypi.python.org/packages/source/S/SQLAlchemy/${name}.tar.gz";
@@ -9231,13 +9219,13 @@ rec {
 
   wxPython28 = import ../development/python-modules/wxPython/2.8.nix {
     inherit (pkgs) stdenv fetchurl pkgconfig;
-    inherit pythonPackages;
+    inherit pythonPackages isPyPy python;
     wxGTK = pkgs.wxGTK28;
   };
 
   wxPython30 = import ../development/python-modules/wxPython/3.0.nix {
     inherit (pkgs) stdenv fetchurl pkgconfig;
-    inherit pythonPackages;
+    inherit pythonPackages isPyPy python;
     wxGTK = pkgs.wxGTK30;
   };
 
@@ -9397,6 +9385,7 @@ rec {
   zodb3 = buildPythonPackage rec {
     name = "zodb3-${version}";
     version = "3.11.0";
+    disabled = isPyPy;
 
     src = fetchurl {
       url = "http://pypi.python.org/packages/source/Z/ZODB3/ZODB3-${version}.tar.gz";
@@ -9415,6 +9404,8 @@ rec {
 
   zodb = buildPythonPackage rec {
     name = "zodb-${version}";
+    disabled = isPyPy;
+
     version = "4.0.1";
 
     src = fetchurl {