diff --git a/pkgs/development/interpreters/python/hooks/setuptools-build-hook.sh b/pkgs/development/interpreters/python/hooks/setuptools-build-hook.sh
index 2aec92793825..311590425e68 100644
--- a/pkgs/development/interpreters/python/hooks/setuptools-build-hook.sh
+++ b/pkgs/development/interpreters/python/hooks/setuptools-build-hook.sh
@@ -29,7 +29,8 @@ setuptoolsShellHook() {
         export PATH="$tmp_path/bin:$PATH"
         export PYTHONPATH="$tmp_path/@pythonSitePackages@:$PYTHONPATH"
         mkdir -p "$tmp_path/@pythonSitePackages@"
-        eval "@pythonInterpreter@ -m pip install -e . --prefix $tmp_path >&2"
+        eval "@pythonInterpreter@ -m pip install -e . --prefix $tmp_path \
+          --no-build-isolation >&2"
     fi
 
     runHook postShellHook