diff --git a/pkgs/development/tools/analysis/valgrind/default.nix b/pkgs/development/tools/analysis/valgrind/default.nix
index 599e9dbd71e5..23b6f5e08fab 100644
--- a/pkgs/development/tools/analysis/valgrind/default.nix
+++ b/pkgs/development/tools/analysis/valgrind/default.nix
@@ -17,6 +17,15 @@ stdenv.mkDerivation {
   configureFlags =
     if stdenv.system == "x86_64-linux" then ["--enable-only64bit"] else [];
 
+  postInstall = ''
+    for i in $out/lib/valgrind/*.supp; do
+      substituteInPlace $i \
+        --replace 'obj:/lib' 'obj:*/lib' \
+        --replace 'obj:/usr/X11R6/lib' 'obj:*/lib' \
+        --replace 'obj:/usr/lib' 'obj:*/lib'
+    done
+  '';
+
   meta = {
     homepage = http://www.valgrind.org/;
     description = "Valgrind, a debugging and profiling tool suite";