diff --git a/pkgs/development/python-modules/cupy/default.nix b/pkgs/development/python-modules/cupy/default.nix
index d23d5bef0e49..2b38f4a9e36e 100644
--- a/pkgs/development/python-modules/cupy/default.nix
+++ b/pkgs/development/python-modules/cupy/default.nix
@@ -1,16 +1,16 @@
 { stdenv, buildPythonPackage
-, fetchPypi, isPy3k, linuxPackages, gcc5
+, fetchPypi, isPy3k, linuxPackages
 , fastrlock, numpy, six, wheel, pytest, mock
 , cudatoolkit, cudnn, nccl
 }:
 
 buildPythonPackage rec {
   pname = "cupy";
-  version = "5.2.0";
+  version = "5.4.0";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "664acff0e1094f0135acca8899318d300258b704e049b1ef0c59154912da53b2";
+    sha256 = "1qms1kmzr543hz30jmcmx20cf9xbgzl97a9k44xizsk785dwakbn";
   };
 
   checkInputs = [
@@ -18,10 +18,6 @@ buildPythonPackage rec {
     mock
   ];
 
-  nativeBuildInputs = [
-    gcc5
-  ];
-
   propagatedBuildInputs = [
     cudatoolkit
     cudnn
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 99be472edfb0..8e7c1a54799b 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1285,9 +1285,9 @@ in {
   cufflinks = callPackage ../development/python-modules/cufflinks { };
 
   cupy = callPackage ../development/python-modules/cupy {
-    cudatoolkit = pkgs.cudatoolkit_8;
-    cudnn = pkgs.cudnn6_cudatoolkit_8;
-    nccl = pkgs.nccl;
+    cudatoolkit = pkgs.cudatoolkit_10_0;
+    cudnn = pkgs.cudnn_cudatoolkit_10_0;
+    nccl = pkgs.nccl_cudatoolkit_10;
   };
 
   cx_Freeze = callPackage ../development/python-modules/cx_freeze {};