diff --git a/pkgs/development/python-modules/libusb1/default.nix b/pkgs/development/python-modules/libusb1/default.nix
index 245ea90038ea..8a9b5da68ef9 100644
--- a/pkgs/development/python-modules/libusb1/default.nix
+++ b/pkgs/development/python-modules/libusb1/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, lib, buildPythonPackage, fetchPypi, python, libusb1 }:
+{ stdenv, lib, buildPythonPackage, fetchPypi, python, libusb1, pytest }:
 
 buildPythonPackage rec {
   pname = "libusb1";
@@ -9,7 +9,7 @@ buildPythonPackage rec {
     sha256 = "a49917a2262cf7134396f6720c8be011f14aabfc5cdc53f880cc672c0f39d271";
   };
 
-  postPatch = lib.optionalString stdenv.isLinux ''
+  postPatch = ''
     substituteInPlace usb1/libusb1.py --replace \
       "ctypes.util.find_library(base_name)" \
       "'${libusb1}/lib/libusb-1.0${stdenv.hostPlatform.extensions.sharedLibrary}'"
@@ -17,8 +17,12 @@ buildPythonPackage rec {
 
   buildInputs = [ libusb1 ];
 
+  checkInputs = [ pytest ];
+
   checkPhase = ''
-    ${python.interpreter} -m usb1.testUSB1
+    # USBPollerThread is unreliable. Let's not test it.
+    # See: https://github.com/vpelletier/python-libusb1/issues/16
+    py.test -k 'not testUSBPollerThreadExit' usb1/testUSB1.py
   '';
 
   meta = with stdenv.lib; {