diff --git a/pkgs/applications/science/biology/octopus/default.nix b/pkgs/applications/science/biology/octopus/default.nix
index b61a0764f2c2..95912d3a7c32 100644
--- a/pkgs/applications/science/biology/octopus/default.nix
+++ b/pkgs/applications/science/biology/octopus/default.nix
@@ -1,28 +1,16 @@
-{lib, stdenv, fetchpatch, fetchFromGitHub, cmake, boost, gmp, htslib, zlib, xz, pkg-config}:
+{lib, stdenv, fetchFromGitHub, cmake, boost, gmp, htslib, zlib, xz, pkg-config}:
 
 stdenv.mkDerivation rec {
   pname = "octopus";
-  version = "0.7.3";
+  version = "0.7.4";
 
   src = fetchFromGitHub {
     owner = "luntergroup";
     repo = "octopus";
     rev = "v${version}";
-    sha256 = "sha256-sPOBZ0YrEdjMNVye/xwqwA5IpsLy2jWN3sm/ce1fLg4=";
+    sha256 = "sha256-FAogksVxUlzMlC0BqRu22Vchj6VX+8yNlHRLyb3g1sE=";
   };
 
-  patches = [
-    # Backport TZ patchs (https://github.com/luntergroup/octopus/issues/149)
-    (fetchpatch {
-      url = "https://github.com/luntergroup/octopus/commit/3dbd8cc33616129ad356e99a4dae82e4f6702250.patch";
-      sha256 = "sha256-UCufVU9x+L1zCEhkr/48KFYRvh8w26w8Jr+O+wULKK8=";
-    })
-    (fetchpatch {
-      url = "https://github.com/luntergroup/octopus/commit/af5a66a2792bd098fb53eb79fb4822625f09305e.patch";
-      sha256 = "sha256-r8jv6EZHfTWVLYUBau3F+ilOd9IeH8rmatorEY5LXP4=";
-    })
-  ];
-
   nativeBuildInputs = [ cmake pkg-config ];
   buildInputs = [ boost gmp htslib zlib xz ];